Studies of aluminum neurobehavioral toxicity in the intact mammal

RA Yokel, DD Allen, JJ Meyer - Cellular and molecular neurobiology, 1994 - Springer
Aluminum (Al) has been implicated in neurotoxic syndromes in several conditions, including
Alzheimer's disease (AD). The developmental stage of the mammalian brain most …

Aluminum intoxication and the victim of Alzheimer's disease: similarities and differences.

RA Yokel, SD Provan, JJ Meyer, SR Campbell - Neurotoxicology, 1988 - europepmc.org
Aluminum (Al) has been implicated in the pathogenesis and may produce a model of senile
dementia of the Alzheimer's type (SDAT). To better understand the effects of Al on the …

Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease

J Savory, MM Herman, O Ghribi - Journal of Alzheimer's …, 2006 - content.iospress.com
For four decades the controversial question concerning a possible role for aluminum
neurotoxicity in contributing to the pathogenesis of Alzheimer's disease has been debated …

Effects of oral aluminum exposure on behavior and neurogenesis in a transgenic mouse model of Alzheimer's disease

D Ribes, MT Colomina, P Vicens, JL Domingo - Experimental Neurology, 2008 - Elsevier
The effects of a very low oral dose of Al on spatial learning and neurogenesis were
evaluated in a transgenic mouse (Tg 2576) model of Alzheimer disease. At 5 months of age …

Effect of aluminum upon conditioned avoidance response acquisition in the absence of neurofibrillary degeneration

GA King, U De Boni, DR Crapper - Pharmacology Biochemistry and …, 1975 - Elsevier
Aluminum induces neurofibrillary degeneration in cats but not rats. Cats develop a
progressive encephalopathy in which an early manifestation is impaired learning-memory …

The effect of age on aluminum retention in rats

M Gómez, DJ Sánchez, JM Llobet, J Corbella… - Toxicology, 1997 - Elsevier
The present study was designed to assess potential changes in aluminum (Al) retention
during advanced age. Young (21 day old), adult (8 months), and old (16 months) rats were …

Aluminium toxicity in the rat brain: histochemical and immunocytochemical evidence

B Platt, G Fiddler, G Riedel, Z Henderson - Brain research bulletin, 2001 - Elsevier
Although the neurotoxic actions of aluminium (Al) have been well documented, its
contribution to neurodegenerative diseases such as Alzheimer's disease remains …

The influence of developmental period of aluminum exposure on synaptic plasticity in the adult rat dentate gyrus in vivo

M Wang, JT Chen, DY Ruan, YZ Xu - Neuroscience, 2002 - Elsevier
Previous studies from our group have demonstrated that chronic aluminum exposure from
parturition throughout life impairs both long-term potentiation (LTP) and long-term …

Aluminum induced encephalopathy in the rat

JJ Lipman, SP Colowick, PL Lawrence, NN Abumrad - Life sciences, 1988 - Elsevier
Aluminum tartrate (AlT) but not sodium tartrate (NaT) produces a progressive
encephalopathy when injected intracerebroventricularly in the rat. This syndrome, lethal …

Aluminum produces age related behavioral toxicity in the rabbit

RA Yokel - Neurotoxicology and teratology, 1989 - Elsevier
Abstract Two-to 3.4-year-old, retired breeder, rabbits received repeated aluminum (Al)
lactate or sodium (Na) lactate injections. All six rabbits receiving twenty 400 μmole Al/kg SC …