Sheppard, David N., and Michael J. Welsh. Structure and Function of the CFTR Chloride
Channel. Physiol. Rev. 79, Suppl.: S23–S45, 1999.—The cystic fibrosis transmembrane …

▪ Abstract The assembly of the cystic fibrosis transmembrane regulator (CFTR) chloride
channel is of interest from the broad perspective of understanding how ion channels and …

Schwiebert, Erik M., Dale J. Benos, Marie E. Egan, M. Jackson Stutts, and William B.
Guggino. CFTR Is a Conductance Regulator as well as a Chloride Channel. Physiol. Rev …

Michael J. Welsh'and Alan E. Smith+'Howard Hughes Medical Institute Departments of
Internal Medicine and of Physiology and Biophysics University of Iowa College of Medicine …

Since the sequence of the CFTR1 ClJ channel was discovered, the function of its R domain
has been puzzling. CFTR is a member of the ATP-binding cassette (ABC) transporter family …

The cystic fibrosis transmembrane conductance regulator (CFTR) functions as a Cl− channel
important in transepithelial salt and water transport. While there is a paucity of direct …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent
protein kinase (PKA)-and ATP-regulated chloride channel, whose gating process involves …

CFTR is a cyclic AMP (cAMP)-activated chloride (Cl−) channel and a regulator of outwardly
rectifying Cl− channels (ORCCs) in airway epithelia. CFTR regulates ORCCs by facilitating …

The cystic fibrosis transmembrane conductance regulator (CFTR) Cl-channel contains two
cytoplasmic nucleotide-binding domains (NBDs). After phosphorylation of the R domain …

The cystic fibrosis transmembrane conductance regulator (CFTR) protein forms a Cl−
channel found in the plasma membranes of many epithelial cells, including those of the …