Background Migraine is considered a multifactorial genetic disorder. Different platforms and
methods are used to unravel the genetic basis of migraine. Initially, linkage analysis in …

The aim of genetic studies in migraine is to identify key proteins in order to better understand
the molecular mechanisms of this frequent but still incompletely understood condition. This …

Migraine is a common genetically linked neurovascular disorder. Approximately∼ 12% of
the Caucasian population are affected including 18% of adult women and 6% of adult men …

The person-to-person variability of drug response is a major problem in clinical practice and
in drug development. It can lead to therapeutic failure or adverse drug reactions (ADRs) in …

Migraine with and without aura (MA and MO, respectively) have a strong genetic basis.
Different approaches using linkage-, candidate gene-and genome-wide association studies …

Migraine is a chronic, paroxysmal, neurologic disorder with widely varying symptoms,
affecting up to 16% of the general population. 127 Although the pathophysiology of parts of …

Recent technical advances in genetics made large-scale genome-wide association studies
(GWAS) in migraine feasible and have identified over 40 common DNA sequence variants …

Migraine is a hereditary disease, usually one-sided, sometimes bilateral. It is characterized
by moderate to severe pain, which worsens with physical activity and may be associated …

Various explanations for the pathophysiology of migraines have been proposed; however,
none of these provide a complete explanation. The author critically reviews previous …

Objective Numerous genetic variants from meta-analyses of observational studies and
GWAS were reported to be associated with migraine susceptibility. However, due to the …