Exploring the therapeutic potential of Cu (II)-complexes with ligands derived from pyridoxal

P Nunes, F Marques, I Cavaco, JC Pessoa… - Inorganica Chimica …, 2020 - Elsevier
Three new copper (II) complexes formulated as [Cu (L)(X)], where X= H 2 O or Cl and H 2 L
is a Schiff base (H 2 L 1, 2) or its reduced version (H 3 L 3 Cl) derived from pyridoxal, are …

Copper (II) complexes of coumarin-derived Schiff base ligands: Pro-or antioxidant activity in MCF-7 cells?

L MacLean, D Karcz, H Jenkins, S McClean… - Journal of inorganic …, 2019 - Elsevier
A series of copper (II) complexes of Schiff base-derived ligands (1–7) were studied for their
pro-and antioxidant behaviour in the MCF-7 human breast cancer cell line. The coordination …

Copper (II) complexes of phenanthroline and histidine containing ligands: Synthesis, characterization and evaluation of their DNA cleavage and cytotoxic activity

SMG Leite, LMP Lima, S Gama, F Mendes… - Inorganic …, 2016 - ACS Publications
Copper (II) complexes have been intensely investigated in a variety of diseases and
pathological conditions due to their therapeutic potential. The development of these …

New Cu (II) complexes with pyrazolyl derived Schiff base ligands: Synthesis and biological evaluation

N Ribeiro, S Roy, N Butenko, I Cavaco… - Journal of inorganic …, 2017 - Elsevier
Since the discovery of cisplatin there has been a continuous pursuit for new metallodrugs
showing higher efficacies and lower side effects. In this work, new copper (II) complexes (C1 …

Novel copper (II) complexes as new promising antitumour agents. A crystal structure of [Cu (1, 10-phenanthroline-5, 6-dione) 2 (OH2)(OClO3)](ClO4)

T Pivetta, F Trudu, E Valletta, F Isaia… - Journal of Inorganic …, 2014 - Elsevier
The cytotoxic properties of copper (II) complexes with 1, 10-phenanthroline (phen) can be
modified by substitution in the phen backbone. For this purpose, Cu (II) complexes with …

Anticancer activities and DNA/BSA interactions for five Cu (II) compounds with substituted terpyridine ligands

X Guan, H Wen, B Wang, Z Wang, Y Zhou… - Journal of …, 2023 - Taylor & Francis
The reactions of copper chloride and 4′-(4′-substituted-phenyl)-2, 2′: 6′, 2′′-
terpyridine ligands bearing nitro (L1), methyl (L2), phenyl (L3), tolyl (L4) and carboxyl (L5) …

[HTML][HTML] Novel Biotinylated Cu (II)-Phenanthroline Complexes: 2D and 3D Cytotoxic Activity and Mechanistic Insight

S Barrett, M De Franco, C Donati, C Marzano, V Gandin… - Molecules, 2023 - mdpi.com
The interest in the use of copper as a metal scaffold for the development of novel
chemotherapeutics has considerably grown in recent years. This is mainly due to the …

[HTML][HTML] Copper (II) phenanthroline-based complexes as potential anticancer drugs: a walkthrough on the mechanisms of action

S Masuri, P Vaňhara, MG Cabiddu, L Moráň, J Havel… - Molecules, 2021 - mdpi.com
Copper is an endogenous metal ion that has been studied to prepare a new antitumoral
agent with less side-effects. Copper is involved as a cofactor in several enzymes, in ROS …

Cytotoxic copper (II) mixed ligand complexes: Crystal structure and DNA cleavage activity

VM Manikandamathavan, RP Parameswari… - European journal of …, 2011 - Elsevier
Two new mixed ligand complexes of copper (II) containing an imidazolyl terpyridine
ligand,[Cu (Itpy)(bpy)](ClO4) 2·(H2O), 1, and [Cu (Itpy)(phen)(ClO4)](ClO4)·(H2O), 2 have …

Design, synthesis, ligand's scaffold variation and structure elucidation of Cu (II) complexes; in vitro DNA binding, morphological studies and their anticancer activity

S Yousuf, F Arjmand, S Tabassum - Polyhedron, 2021 - Elsevier
Two new copper (II) complexes, Cu [(L) 2 (X)](1) and Cu [(L)(X) 2](2) where L= 1, 10-
phenanthroline and X=(2-pyrimidylthio)-acetic acid (PTAA), have been synthesized and …