The apicoplast is an essential plastid organelle found in Plasmodium parasites which
contains several clinically validated antimalarial-drug targets. A chemical rescue screen …

Plasmodium spp parasites harbor an unusual plastid organelle called the apicoplast. Due to
its prokaryotic origin and essential function, the apicoplast is a key target for development of …

Compounds that target isoprenoid biosynthesis in Plasmodium falciparum could be a
welcome addition to malaria chemotherapy, since the methylerythritol phosphate (MEP) …

As resistance to current therapies spreads, novel antimalarials are urgently needed. In this
work, we examine the potential for therapeutic intervention via the targeting of Plasmodium …

Isoprenoid precursor synthesis is an ancient and fundamental function of plastid organelles
and a critical metabolic activity of the apicoplast in Plasmodium malaria parasites [–]. Over …

The MEP (Methyl Erythritol Phosphate) isoprenoids biosynthesis pathway is an attractive
drug target to combat malaria, due to its uniqueness and indispensability for the parasite. It …

Malaria parasites contain a relict plastid, the apicoplast, which is considered an excellent
drug target due to its bacterial-like ancestry. Numerous parasiticidals have been proposed to …

The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted
efforts to identify and validate agents with novel mechanisms of action. MEPicides represent …

Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that
selectively target apicoplast housekeeping functions, including DNA replication and protein …

Malaria parasites rely on a plastid organelle for survival during the blood stages of infection.
However, the entire organelle is dispensable as long as the isoprenoid precursor …