Multidrug-resistant Acinetobacter baumannii, a common pathogen responsible for
nosocomial infections, is the main cause for outbreaks of infectious diseases, such as …

Inflammasomes are intracellular signaling complexes that are assembled in response to a
variety of pathogenic or physiologic stimuli to initiate inflammatory responses. Ubiquitously …

Inflammasome activation is critical for host defenses against various microbial infections.
Activation of the NLRC4 inflammasome requires detection of flagellin or type III secretion …

Interferons (IFNs) were discovered over a half-century ago as antiviral factors. The role of
type I IFNs has been studied in the pathogenesis of both acute and chronic microbial …

Abstract Streptococcus pneumoniae (S. pneumoniae), a clinically important pathogen
worldwide, causes serious invasive diseases, such as pneumonia, otitis media, and …

The type I interferon pathway plays a critical role in both host defense and tolerance against
viral infection and thus requires refined regulatory mechanisms. RIPK3-mediated …

Recognition of intracellular pathogenic bacteria by members of the nucleotide-binding
domain and leucine-rich repeat containing (NLR) family triggers immune responses against …

RIPK1 kinase activity has been shown to be essential to driving pyroptosis, apoptosis, and
necroptosis. However, here we show a kinase activity–independent role for RIPK1 in these …

Activation of caspase-11 by some Gram-negative bacteria triggers the caspase-1/interleukin
1β (IL-1β) pathway, independent of canonical inflammasomes. Acinetobacter baumannii is a …

Respiratory epithelial cell death by influenza virus infection is responsible for the induction
of inflammatory responses, but the exact cell death mechanism is not understood. Here we …