Mutations in MEFV, the gene encoding pyrin in humans, are associated with the
autoinflammatory disorder familial Mediterranean fever. Pyrin is an innate sensor that …

Influenza A virus (IAV) continues to pose a significant global health threat, causing severe
respiratory infections that result in substantial annual morbidity and mortality. Recent …

Mesenchymal stem cells (MSCs) have been used in cell-based therapies for a variety of
disorders. Some factors such as inflammatory mediators in the diseased area might damage …

Shigella deploys a unique mechanism to manipulate macrophage pyroptosis by delivering
the IpaH7. 8 E3 ubiquitin ligase via its type III secretion system. IpaH7. 8 ubiquitinates …

Programmed cell death and especially necroptosis, a programmed and regulated form of
necrosis, have been recently implicated in the progression and outcomes of influenza in …

The NLRP3 inflammasome plays a central role in antimicrobial defense, as well as in sterile
inflammatory conditions. NLRP3 activity is governed by two independent signals. The first …

The potassium ionophore nigericin induces cell death and promotes the maturation and
release of IL-1β in lipopolysaccharide (LPS)-primed monocytes and macrophages, the latter …

Streptococcus pneumoniae, a Gram-positive bacterial pathogen, causes pneumonia,
meningitis, and septicemia. Innate immune responses are critical for the control and …

Systemic infections with Gram-negative bacteria are characterized by high mortality rates
due to the" sepsis syndrome," a widespread and uncontrolled inflammatory response …

Mitochondria play an essential role in energy metabolism. Oxygen deprivation can poison
cells and generate a chain reaction due to the free radical release. In patients with sepsis …