The NLRP3 inflammasome plays a central role in antimicrobial defense as well as in the
context of sterile inflammatory conditions. NLRP3 activity is governed by two independent …

ABSTRACT NLRP3 inflammasome mainly controls interleukin-1β (IL-1β) secretion, leading
to cell death called pyroptosis constituting a major antiviral host defense and inflammatory …

Background Mycoplasma pneumoniae is a predominant cause of community-acquired
respiratory infections. We recently discovered the clinical efficacy of Maxing shigan …

Pathogenic infections and tissue injuries trigger the assembly of inflammasomes, cytosolic
protein complexes that activate caspase-1, leading to cleavage of pro-IL-1β and pro-IL-18 …

Inflammasome is a cytosolic multiprotein complex to activate caspase-1 leading to the
subsequent processing of inactive pro-interleukin-1-beta (Pro-IL-1β) into its active …

Mitophagy is a selective autophagy targeting damaged and potential cytotoxic mitochondria,
which can effectively prevent excessive cytotoxic production from damaged mitochondria …

The COVID-19 pandemic has caused significant morbidity and mortality. Currently, there is a
critical shortage of proven treatment options and an urgent need to understand the …

Neuronal apoptosis inhibitory protein (NAIP)/NOD-like receptor (NLR) containing a caspase
activating and recruitment domain (CARD) 4 (NLRC4) inflammasome complexes are …

TRK-fused gene (TFG) is known to be involved in protein secretion and plays essential roles
in an antiviral innate immune response. However, its function in LPS-induced inflammation …

Type I interferons (IFNs) are secreted by many cell types upon stimulation via pattern
recognition receptors and bind to IFN-α/β receptor (IFNAR), which is composed of IFNAR1 …