Background The impact of gender-affirming testosterone on fertility is poorly understood,
with ovarian histopathologic studies showing variable results, some with a detrimental effect …

Transgender and nonbinary people with female birth sex may utilize testosterone therapy for
masculinization. Individuals interested in reproduction using their own gametes should be …

Some transmasculine individuals may be interested in pausing gender-affirming
testosterone therapy and carrying a pregnancy. The ovarian impact of taking and pausing …

STUDY QUESTION Does testosterone use in females affect reproductive potential,
particularly with regard to the production of fertilizable gametes? SUMMARY ANSWER …

In brief Animal studies are needed to inform clinical guidance on the effects of testosterone
gender-affirming hormone therapy (T-GAHT) on fertility. This review summarizes current …

Testosterone therapy prompts the development of male secondary sexual characteristics
coupled with numerous physiological changes; however, the effect of prolonged androgen …

Abstract Purpose of Review Hormonal and surgical treatments for transgender individuals
can severely impact reproductive potential. In this review, we discuss the role of fertility …

Testosterone gender affirming hormone therapy (T-GAHT) is frequently used by transgender
and gender-diverse individuals assigned female at birth to establish masculinizing …

STUDY QUESTION Can mice serve as a translational model to investigate the reproductive
effects of testosterone (T) therapy commonly used by transgender men? SUMMARY …

Androgens are essential in normal ovarian function and follicle health, but
hyperandrogenism, as seen in polycystic ovary syndrome, is associated with disordered …