Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the
further expansion of (pre-) malignant cells,. Key signalling components of the senescence …

Normal cells can respond to expression of activated oncogenes by initiating cellular
senescence, a permanent state of proliferative arrest. But whether this process reflects a …

Aberrant activation of oncogenes or loss of tumour suppressor genes opposes malignant
transformation by triggering a stable arrest in cell growth, which is termed cellular …

Activated oncogenes and anticancer chemotherapy induce cellular senescence, a terminal
growth arrest of viable cells characterized by S-phase entry-blocking histone 3 lysine 9 …

Cellular senescence is implicated in physiological and pathological processes spanning
development, wound healing, age-related decline in organ functions and cancer. Here, we …

Disseminated cancer cells from primary tumours can seed in distal tissues, but may take
several years to form overt metastases, a phenomenon that is termed tumour dormancy …

Cellular senescence has historically been viewed as an irreversible cell-cycle arrest
mechanism that acts to protect against cancer, but recent discoveries have extended its …

Many organs with a high cell turnover (for example, skin, intestine and blood) are composed
of short-lived cells that require continuous replenishment by somatic stem cells,. Ageing …

Activated oncogenes or anticancer therapies evoke senescent cell-cycle arrest in (pre-)
malignant cells, thereby interrupting tumor formation or progression. Physiologically, cellular …

Activated oncogenes induce compensatory tumour-suppressive responses, such as cellular
senescence or apoptosis, but the signals determining the main outcome remain to be fully …