Clonally expanded CD8+ T lymphocytes are present in multiple sclerosis lesions, as well as
in the cerebrospinal fluid of patients with multiple sclerosis. In experimental autoimmune …

Activated CD4 Th1 lymphocytes can enter the brain in the absence of an inflammatory focus.
However, the molecular mediators that regulate this early migration of lymphocytes into the …

Multiple sclerosis is an inflammatory demyelinating disease in which active demyelination
and neurodegeneration are associated with lymphocyte infiltrates in the brain. However, so …

We used adult human brain-derived endothelial cells (HBECs) to model migration of
peripheral blood lymphocytes across the blood brain barrier (BBB) as occurs in MS. We …

Strong evidence supports that CNS-specific CD4+ T cells are central to the pathogenesis of
multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Using a model of …

We have used human brain-derived endothelial cells (HBECs) maintained under basal
culture conditions in a Boyden chamber assay system as an in vitro model of migration of …

CCR7 and CD45RA expression on CD4+ and CD8+ T-cells in blood (PB) of 16 patients with
multiple sclerosis (MS) and 16 healthy controls and cerebrospinal fluid (CSF) of 10 patients …

Objective The onset of neurological signs in experimental autoimmune encephalomyelitis is
tightly associated with infiltration and reactivation of T cells in the central nervous system …

Although CD8 T cells are key players in neuroinflammation, little is known about their
trafficking cues into the central nervous system (CNS). We used a murine model of CNS …

We review the contribution made by CD8+ T cells to inflammation in the central nervous
system (CNS) in Multiple Sclerosis (MS), and discuss their role in the animal model …