Immunization with myelin antigens leads to the development of experimental autoimmune
encephalomyelitis, an animal model of multiple sclerosis. The disease can also be induced …

To investigate the regulatory interactions among autologous T-cells during the course of
multiple sclerosis (MS), proteolipid protein peptide-specific CD4+ T-cell clones (TCCs) were …

Multiple sclerosis (MS) is the prototypic inflammatory disease of the central nervous system
(CNS) characterized by multifocal areas of demyelination, axonal damage, activation of glial …

The role of CD8+ T cells in multiple sclerosis (MS) and its animal models has been
enigmatic. Most studies of MS have focused on the role of CD4+ Th1 T cells and many …

Myelin-specific CD8+ T cells are thought to contribute to the pathogenesis of multiple
sclerosis. Here we modeled this contribution in mice with CD8+ T cells recognizing …

Although multiple sclerosis (MS) is a presumed T-cell-mediated disease, it is unclear what
triggers the development of neuroantigen-specific T cells. Autoreactive CD4+ T cells are …

Neuroinflammation is an emerging focus of translational stroke research. Preclinical studies
have demonstrated a critical role for brain-invading lymphocytes in post-stroke …

Chemokines and their receptors may be implicated in leukocyte ingress into brain during
inflammation observed during the course of multiple sclerosis (MS). To address receptor …

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the CNS, and CD8
T cells are the predominant T cell population in MS lesions. Given that transfer of CNS …

In chronic inflammatory diseases of the central nervous system (CNS), immune cells
persisting behind the blood-brain barrier are supposed to promulgate local tissue …