The migration of lymphocytes through primary cultures of rat brain microvascular endothelial
cell monolayers was examined in vitro by time-lapse videomicroscopy. Antigen-specific T …

Feline brain endothelial cells (BECs), astrocytes, and microglia were combined in different
configurations in a cell culture insert system to assess the effect of different cell types on the …

Background and Purpose—Cerebral ischemia is ensued by a cellular immune depression
syndrome. The postischemic functional capacity of T lymphocytes is controversial, and …

Upon inflammation, stimulated, but not resting T lymphocytes cross the blood‐brain barrier
and migrate into the central nervous system. This study shows that direct contact between …

T cells have an essential role in the induction of multiple sclerosis and its animal model
experimental autoimmune encephalomyelitis (EAE). Although for CD4+ T cells it is well …

CD8 T cell infiltration of the central nervous system (CNS) is necessary for host protection
but contributes to neuropathology. Antigen presenting cells (APCs) situated at CNS borders …

Experimental stroke leads to microglia activation and progressive neuronal loss at sites of
secondary neurodegeneration (SND). These lesions are remote from, but synaptically …

Although the CNS is immune privileged, continuous search for pathogens and tumours by
immune cells within the CNS is indispensable. Thus, distinct immune-cell populations also …

Lymphocytes depend on endothelial adhesion molecules such as ICAM-1 and VCAM-1,
upregulated with inflammation, to facilitate transmigration across junctional barriers. New …

Blood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous
system (CNS) are early hallmarks of multiple sclerosis (MS). High numbers of CD8+ T cells …