Although microglial activation occurs in inflammatory, degenerative and neoplastic central
nervous system (CNS) disorders, its role in pathogenesis is unclear. We studied this …

Microglia, the parenchymal brain macrophages of the central nervous system, have
emerged as critical players in brain development and homeostasis. The immune functions of …

Hematopoietic stem cell transplantation (HSCT) is a therapy used for multiple malignant and
nonmalignant diseases, with chemotherapy used for pretransplantation myeloablation. The …

Pro-inflammatory T cells in the central nervous system (CNS) are causally associated with
multiple demyelinating and neurodegenerative diseases,,,,–, but the pathways that control …

The cytokine transforming growth factor-β (TGF-β) regulates the development and
homeostasis of several tissue-resident macrophage populations, including microglia. TGF-β …

Systemic lupus erythematosus (SLE) is an incurable autoimmune disease characterized by
autoantibody deposition in tissues such as kidney, skin and lungs. Notably, up to 75% of …

The role of microglia and monocyte-derived macrophages in experimental autoimmune
encephalomyelitis pathogenesis has been controversial. To gain insight into their respective …

Microglia and astrocytes modulate inflammation and neurodegeneration in the central
nervous system (CNS),–. Microglia modulate pro-inflammatory and neurotoxic activities in …

Multiple sclerosis: trapped in deadly glue | Nature Medicine Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

There has been an explosion of new findings recently giving us insights into the involvement
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …