Experimental autoimmune encephalomyelitis repressed by microglial paralysis
Although microglial activation occurs in inflammatory, degenerative and neoplastic central
nervous system (CNS) disorders, its role in pathogenesis is unclear. We studied this …
nervous system (CNS) disorders, its role in pathogenesis is unclear. We studied this …
Cognate microglia–T cell interactions shape the functional regulatory T cell pool in experimental autoimmune encephalomyelitis pathology
Z Haimon, GR Frumer, JS Kim, S Trzebanski… - Nature …, 2022 - nature.com
Microglia, the parenchymal brain macrophages of the central nervous system, have
emerged as critical players in brain development and homeostasis. The immune functions of …
emerged as critical players in brain development and homeostasis. The immune functions of …
Hematopoietic stem cell transplantation chemotherapy causes microglia senescence and peripheral macrophage engraftment in the brain
Hematopoietic stem cell transplantation (HSCT) is a therapy used for multiple malignant and
nonmalignant diseases, with chemotherapy used for pretransplantation myeloablation. The …
nonmalignant diseases, with chemotherapy used for pretransplantation myeloablation. The …
Antigen-presenting innate lymphoid cells orchestrate neuroinflammation
Pro-inflammatory T cells in the central nervous system (CNS) are causally associated with
multiple demyelinating and neurodegenerative diseases,,,,–, but the pathways that control …
multiple demyelinating and neurodegenerative diseases,,,,–, but the pathways that control …
Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling
The cytokine transforming growth factor-β (TGF-β) regulates the development and
homeostasis of several tissue-resident macrophage populations, including microglia. TGF-β …
homeostasis of several tissue-resident macrophage populations, including microglia. TGF-β …
Microglia-dependent synapse loss in type I interferon-mediated lupus
AR Bialas, J Presumey, A Das, CE van der Poel… - Nature, 2017 - nature.com
Systemic lupus erythematosus (SLE) is an incurable autoimmune disease characterized by
autoantibody deposition in tissues such as kidney, skin and lungs. Notably, up to 75% of …
autoantibody deposition in tissues such as kidney, skin and lungs. Notably, up to 75% of …
RNA sequencing of microglia and monocyte-derived macrophages from mice with experimental autoimmune encephalomyelitis illustrates a changing phenotype with …
ND Lewis, JD Hill, KW Juchem… - Journal of …, 2014 - Elsevier
The role of microglia and monocyte-derived macrophages in experimental autoimmune
encephalomyelitis pathogenesis has been controversial. To gain insight into their respective …
encephalomyelitis pathogenesis has been controversial. To gain insight into their respective …
Microglial control of astrocytes in response to microbial metabolites
V Rothhammer, DM Borucki, EC Tjon, MC Takenaka… - Nature, 2018 - nature.com
Microglia and astrocytes modulate inflammation and neurodegeneration in the central
nervous system (CNS),–. Microglia modulate pro-inflammatory and neurotoxic activities in …
nervous system (CNS),–. Microglia modulate pro-inflammatory and neurotoxic activities in …
Multiple sclerosis: trapped in deadly glue
M Platten, L Steinman - Nature medicine, 2005 - nature.com
Multiple sclerosis: trapped in deadly glue | Nature Medicine Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain …
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Microglia emerge as central players in brain disease
MW Salter, B Stevens - Nature medicine, 2017 - nature.com
There has been an explosion of new findings recently giving us insights into the involvement
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …