Impact of the nanoparticle–protein corona on colloidal stability and protein structure

JS Gebauer, M Malissek, S Simon, SK Knauer… - Langmuir, 2012 - ACS Publications
In biological fluids, proteins may associate with nanoparticles (NPs), leading to the formation
of a so-called “protein corona” largely defining the biological identity of the particle. Here, we …

An analysis of the binding function and structural organization of the protein corona

Y Zhang, JLY Wu, J Lazarovits… - Journal of the American …, 2020 - ACS Publications
Blood proteins adsorb onto the surface of nanoparticles after intravenous injection to form a
protein corona. The underlying organization and binding function of these adsorbed proteins …

Biomolecular coronas provide the biological identity of nanosized materials

MP Monopoli, C Aberg, A Salvati… - Nano-Enabled Medical …, 2020 - taylorfrancis.com
Fundamentally, all interactions between the nanoparticle corona complex and the biological
machinery are mediated by physical forces common to all molecular systems. The …

Reversible versus Irreversible Binding of Transferrin to Polystyrene Nanoparticles: Soft and Hard Corona

S Milani, F Baldelli Bombelli, AS Pitek, KA Dawson… - ACS …, 2012 - ACS Publications
Protein adsorption to nanoparticles (NPs) is a key prerequisite to understand NP–cell
interactions. While the layer thickness of the protein corona has been well characterized in …

Protein corona in response to flow: effect on protein concentration and structure

DT Jayaram, SM Pustulka, RG Mannino, WA Lam… - Biophysical …, 2018 - cell.com
Nanoparticles used in cellular applications encounter free serum proteins that adsorb onto
the surface of the nanoparticle, forming a protein corona. This protein layer controls the …

Measurements of heterogeneity in proteomics analysis of the nanoparticle protein corona across core facilities

AA Ashkarran, H Gharibi, E Voke, MP Landry… - Nature …, 2022 - nature.com
Robust characterization of the protein corona—the layer of proteins that spontaneously
forms on the surface of nanoparticles immersed in biological fluids—is vital for prediction of …

In Situ Analysis of Weakly Bound Proteins Reveals Molecular Basis of Soft Corona Formation

D Sanchez-Guzman, G Giraudon--Colas, L Marichal… - ACS …, 2020 - ACS Publications
Few experimental techniques allow the analysis of the protein corona in situ. As a result,
little is known on the effects of nanoparticles on weakly bound proteins that form the soft …

Evolution of the nanoparticle corona

M Hadjidemetriou, K Kostarelos - Nature nanotechnology, 2017 - nature.com
Evolution of the nanoparticle corona | Nature Nanotechnology Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To …

Studying the protein corona on nanoparticles by FCS

GU Nienhaus, P Maffre, K Nienhaus - Methods in enzymology, 2013 - Elsevier
Engineered nanoparticles (NPs) have found widespread application in technology and
medicine. Whenever they come in contact with a living organism, interactions take place …

The effect of surface nanometre-scale morphology on protein adsorption

PE Scopelliti, A Borgonovo, M Indrieri, L Giorgetti… - PloS one, 2010 - journals.plos.org
Background Protein adsorption is the first of a complex series of events that regulates many
phenomena at the nano-bio interface, eg cell adhesion and differentiation, in vivo …