The crown and the scepter: roles of the protein corona in nanomedicine

R Cai, C Chen - Advanced Materials, 2019 - Wiley Online Library
Engineering nanomaterials are increasingly considered promising and powerful biomedical
tools or devices for imaging, drug delivery, and cancer therapies, but few nanomaterials …

Environmental dimensions of the protein corona

KE Wheeler, AJ Chetwynd, KM Fahy, BS Hong… - Nature …, 2021 - nature.com
The adsorption of biomolecules to the surface of engineered nanomaterials, known as
corona formation, defines their biological identity by altering their surface properties and …

Understanding the nanoparticle–protein corona complexes using computational and experimental methods

B Kharazian, NL Hadipour, MR Ejtehadi - The international journal of …, 2016 - Elsevier
Nanoparticles (NP) have capability to adsorb proteins from biological fluids and form protein
layer, which is called protein corona. As the cell sees corona coated NPs, the protein corona …

Role of protein corona in the biological effect of nanomaterials: Investigating methods

L Zeng, J Gao, Y Liu, J Gao, L Yao, X Yang… - TrAC Trends in …, 2019 - Elsevier
Growing developments in engineered nanomaterials (NMs) and their wide applications
inevitably raise environmental and human health concerns. Upon contact with biological …

Physical−Chemical Aspects of Protein Corona: Relevance to in Vitro and in Vivo Biological Impacts of Nanoparticles

MP Monopoli, D Walczyk, A Campbell… - Journal of the …, 2011 - ACS Publications
It is now clearly emerging that besides size and shape, the other primary defining element of
nanoscale objects in biological media is their long-lived protein (“hard”) corona. This corona …

Nanoparticle protein corona: from structure and function to therapeutic targeting

G Bashiri, MS Padilla, KL Swingle, SJ Shepherd… - Lab on a Chip, 2023 - pubs.rsc.org
Nanoparticle (NP)-based therapeutics have ushered in a new era in translational medicine.
However, despite the clinical success of NP technology, it is not well-understood how NPs …

Visualization of the protein corona: towards a biomolecular understanding of nanoparticle-cell-interactions

M Kokkinopoulou, J Simon, K Landfester, V Mailänder… - Nanoscale, 2017 - pubs.rsc.org
The use of nanocarriers in biology and medicine is complicated by the current need to
understand how nanoparticles interact in complex biological surroundings. When …

Quantitative profiling of the protein coronas that form around nanoparticles

D Docter, U Distler, W Storck, J Kuharev, D Wünsch… - Nature protocols, 2014 - nature.com
Nanoparticle applications in biotechnology and biomedicine are steadily increasing. In
biological fluids, proteins bind to nanoparticles that form the protein corona, crucially …

Influence of surface chemistry and morphology of nanoparticles on protein corona formation

R Bilardo, F Traldi, A Vdovchenko… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Nanomaterials offer promising solutions as drug delivery systems and imaging agents in
response to the demand for better therapeutics and diagnostics. However, the limited …

Interplay between nanomedicine and protein corona

M Yang, E Wu, W Tang, J Qian, C Zhan - Journal of Materials …, 2021 - pubs.rsc.org
Nanomedicine is recognized as a promising agent for diverse biomedical applications;
however, its safety and efficiency in clinical practice remains to be enhanced. A priority issue …