Comparative in vitro exoenzyme-suppressing activities of azithromycin and other macrolide antibiotics against Pseudomonas aeruginosa

R Mizukane, Y Hirakata, M Kaku, Y Ishii… - Antimicrobial agents …, 1994 - Am Soc Microbiol
The inhibitory effects of azithromycin (AZM), a new 15-membered macrolide antibiotic, on
the production of exotoxin A, total protease, elastase, and phospholipase C by …

Inhibition of Pseudomonas aeruginosa virulence factors by subinhibitory concentrations of azithromycin and other macrolide antibiotics

G Molinari, CA Guzman, A Pesce… - Journal of Antimicrobial …, 1993 - academic.oup.com
The ability of three macrolide antibiotics (erythromycin, clarithromycin and azithromycin) to
inhibit the expression of several pathogenicity traits of Pseudomonas aeruginosa at …

Inhibition of Pseudomonas aeruginosa exoenzyme expression by subinhibitory antibiotic concentrations

K Grimwood, M To, HR Rabin… - Antimicrobial agents and …, 1989 - Am Soc Microbiol
We examined the effects of subinhibitory concentrations of ciprofloxacin, tobramycin, and
ceftazidime on Pseudomonas aeruginosa exoenzyme expression in vitro and in vivo …

Potential of macrolide antibiotics to inhibit protein synthesis of Pseudomonas aeruginosa: suppression of virulence factors and stress response

K Tateda, Y Ishii, T Matsumoto, T Kobayashi… - Journal of Infection and …, 2000 - Elsevier
Recently we have reported that sub-minimum inhibitory concentrations (MICs) of macrolide
antibiotics, such as erythromycin, clarithromycin, and azithromycin, induce loss of viability of …

Azithromycin Exhibits Bactericidal Effects on Pseudomonas aeruginosa through Interaction with the Outer Membrane

Y Imamura, Y Higashiyama, K Tomono… - Antimicrobial agents …, 2005 - Am Soc Microbiol
The aim of the present study was to elucidate the effect of the macrolide antibiotic
azithromycin on Pseudomonas aeruginosa. We studied the susceptibility to azithromycin in …

Inhibition of motility ofPseudomonas aeruginosa andProteus mirabilis by subinhibitory concentrations of azithromycin

G Molinari, P Paglia, GC Schito - European Journal of Clinical …, 1992 - Springer
Abstract Exposure to subinhibitory concentrations (4–8 µg/ml) of azithromycin resulted in
loss of motility in Proteus mirabilis strains and a significant reduction of motility in …

Direct evidence for antipseudomonal activity of macrolides: exposure-dependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin …

K Tateda, Y Ishii, T Matsumoto, N Furuya… - Antimicrobial agents …, 1996 - Am Soc Microbiol
Several previous investigators have reported that long-term administration of certain
macrolides is efficacious in patients with persistent pulmonary Pseudomonas aeruginosa …

Suppression of virulence factors of Pseudomonas aeruginosa by erythromycin

E Kita, M Sawaki, D Oku, A Hamuro… - Journal of …, 1991 - academic.oup.com
The effects of erythromycin stearate over a concentration range of 0.1–10 mg/l on production
of elastase, protease and leucocidin by clinical isolates of Pseudomonas aeruginosa were …

Subinhibitory antibiotics reduce Pseudomonas aeruginosa tissue injury in the rat lung model

K Grimwood, M To, HR Rabin… - Journal of antimicrobial …, 1989 - academic.oup.com
Using the agar-bcad rat lung model, we evaluated the effects of subinhibitory antibiotic
treatment upon Pseudomonas aeruginosa exoenzyme expression and lung injury in vivo …

The effect of sublethal levels of antibiotics on the pathogenicity of Pseudomonas aeruginosa for tracheal tissue

TA Geers, NR Baker - Journal of Antimicrobial Chemotherapy, 1987 - academic.oup.com
Hamster tracheal organ cultures were used to evaluate the ability of two aminoglycoside and
two β-lactam antibiotics to protect the epithelium from damage due to Pseudomonas …