A carcinoembryonic Ag (CEA)-based DNA vaccine encoding both CEA and CD40 ligand
trimer achieved effective tumor-protective immunity against murine colon carcinoma in CEA …

Dendritic cells (DCs) are antigen-presenting cells that play an important role in antitumor
immunity. Several studies have reported that DCs pulsed with RNA from tumor cells have …

Recent research indicates that dendritic cells transfected with RNA-encoded tumour-
associated antigens (TAA) can generate potent anti-tumour immune responses in vitro and …

Clinical application of dendritic cell (DC) vaccine therapy is hindered by the need for a large
quantity of DCs generated from peripheral blood monocytes of the patient. We investigated …

Therapeutic anticancer vaccines are designed to boost patients' immune responses to
tumors. One approach is to use a viral vector to deliver antigen to in situ DCs, which then …

Pancreatic cancer (PC) is one of the most devastating human malignancies without effective
therapies. Tumor vaccine based on RNA-transfected dendritic cells (DCs) has emerged as …

Background: Human colorectal cancer cells overexpress carcinoembryonic antigen (CEA).
CEA is a glycoprotein which has shown to be a promising vaccine target for immunotherapy …

Immunization with specific tumor-associated antigen (Ag)(TAA)-pulsed dendritic cells (DC)
has proven to be eficacious in a variety of animal models and is being investigated for the …

We present a generic dendritic cell (DC) vaccine strategy for patients with renal cell
carcinoma (RCC) based on the use of RNA as a source of multiplex tumor-associated …

Colon cancer is a common malignancy worldwide and there is an urgent requirement to
develop effective treatment strategies. In recent years, tumor immunotherapy has become a …