To investigate the influence of histone deacetylases on nuclear reprogramming after nuclear
transfer, we treated the cloned embryos with a histone deacetylase inhibitor, Trichostatin A …

The low success rate of animal cloning by somatic cell nuclear transfer (SCNT) is believed to
be associated with aberrant epigenetic nuclear reprogramming. It has been demonstrated …

Low efficiency of somatic cell nuclear transfer (SCNT) is attributed to incomplete
reprogramming of transferred nuclei into oocytes. Trichostatin A (TSA), a histone …

Accumulating evidence suggests that trichostatin A (TSA), a histone deacetylase inhibitor,
can increase the success rate of somatic cloning. The objective of this study was to …

Nuclear reprogramming is dependent upon a number of factors, including chromatin
organization and modification. Trychostatin A (TSA), a histone deacetylase inhibitor, was …

Trichostatin A (TSA), a histone deacetylase inhibitor, has been used to improve nuclear
reprogramming in somatic cell nuclear transfer embryos. However, the molecular …

Until now, the successful cloning of porcine by somatic cell nuclear transfer (SCNT) has
remained low. The effort of using Trichostatin A (TSA), a potent histone deacetylase inhibitor …

Recently, trichostatin A (TSA) and some other histone deacetylase inhibitors (HDACi) were
reported to enhance the development of mouse somatic cell nuclear transfer (SCNT) …

Successful cloning by somatic cell nuclear transfer (SCNT) requires a reprogramming
process in which the epigenetic state of a differentiated donor nucleus must be converted …

We examined the comprehensive epigenetic status, including histone H3 and H4
acetylation, DNA methylation and level of mRNA transcripts of bovine somatic cell nuclear …