28 EFFECT OF TRICHOSTATIN A ON IN VITRO EMBRYO DEVELOPMENT OF INTERSPECIES NUCLEAR TRANSFER EMBRYOS RECONSTRUCTED FROM CAT …

M Wittayarat, Z Namula, VV Luu, LTK Do… - Reproduction, fertility …, 2012 - CSIRO Publishing
Interspecies somatic cell nuclear transfer (iSCNT) is an invaluable tool for studying nucleus-
cytoplasm interactions and may provide an alternative for cloning endangered animals …

Trichostatin A affects histone acetylation and gene expression in porcine somatic cell nucleus transfer embryos

RP Cervera, N Marti-Gutierrez, E Escorihuela… - Theriogenology, 2009 - Elsevier
Epigenetic aberrancies likely preclude correct and complete nuclear reprogramming after
somatic cell nucleus transfer (SCNT) and may underlie the observed reduced viability of …

Donor cell trichostatin A treatment improves the in vitro development of cloned goat embryos

YM Wang, XB Ding, XF Liu, Y Zhang - Small Ruminant Research, 2015 - Elsevier
The low success rate of somatic cell nuclear transfer (SCNT) is primarily due to incomplete
reprogramming of the transferred nuclei. As an inhibitor of histone deacetylase, trichostatin A …

An Epigenetic Modifier Results in Improved In Vitro Blastocyst Production after Somatic Cell Nuclear Transfer

Y Zhang, J Li, K Villemoes, AM Pedersen… - Cloning and stem …, 2007 - liebertpub.com
The present study was designed to examine the effect of trichostatin A (TSA), an inhibitor of
histone deacetylase, on development of porcine cloned embryos. Our results showed that …

Trichostatin A improves histone acetylation in bovine somatic cell nuclear transfer early embryos

AE Iager, NP Ragina, PJ Ross, Z Beyhan… - Cloning and stem …, 2008 - liebertpub.com
Epigenetic aberrancies likely preclude correct and complete nuclear reprogramming
following somatic cell nuclear transfer (SCNT), and may underlie the observed reduced …

Comparison of potency between histone deacetylase inhibitors trichostatin A and valproic acid on enhancing in vitro development of porcine somatic cell nuclear …

YJ Kim, KS Ahn, M Kim, H Shim - In Vitro Cellular & Developmental Biology …, 2011 - Springer
Epigenetic modification influences reprogramming and subsequent development of somatic
cell nuclear transfer (SCNT) embryos. Such modification includes an increase in histone …

Treatment with a histone deacetylase inhibitor after nuclear transfer improves the preimplantation development of cloned bovine embryos

S Akagi, K Matsukawa, E Mizutani… - … of Reproduction and …, 2011 - jstage.jst.go.jp
We examined the effects of treatment with histone deacetylase inhibitors (HDACi),
trichostatin A (TSA) and scriptaid (SCR), on the blastocyst formation rate in bovine somatic …

Effects of Trichostatin A and 5-aza-2'deoxycytidine on Nuclear Reprogramming in Pig Cloned Embryos

SH Lee, YN Xu, YT Heo, XS Cui… - Reproductive and …, 2013 - koreascience.kr
Low efficiency of somatic cell nuclear transfer (SCNT) is attributed to incomplete
reprogramming of transfered nuclei into oocytes. Trichostatin A (TSA), histone deacetylase …

139 TRICHOSTATIN A IMPROVED IN VITRO DEVELOPMENT OF PORCINE NUCLEAR TRANSFER EMBRYOS PRODUCED BY A NEW ACTIVATION METHOD

LC Sui, W Wang, YS Li, YL Zhang, SF Ji… - Reproduction …, 2010 - CSIRO Publishing
Recently, it has been reported that a new activation method, brief exposure to cycloheximide
before electrical activation, could increase development rates and reduce cell death. In our …

Histone deacetylase inhibitor improves the development and acetylation levels of cat–cow interspecies cloned embryos

M Wittayarat, Y Sato, LTK Do, Y Morita… - … " Cloning and Stem …, 2013 - liebertpub.com
Abnormal epigenetic reprogramming, such as histone acetylation, might cause low
efficiency of interspecies somatic cell nuclear transfer (iSCNT). This study was conducted to …