The objective of this study was to investigate the effect of Trichostatin A (TSA) treatment on
the development of intra-and inter-species cloned embryos. The cattle (Bos taurus) …

Somatic cell nuclear transfer (SCNT) efficiency is still low in rabbit. Previous studies
indicated that trichostatin A (TSA) treatment could improve cloning efficiency and term …

The interspecies somatic cell nuclear transfer (iSCNT) technique for therapeutic cloning
gives great promise for treatment of many human diseases. However, the incomplete …

Trichostatin A (TSA) has previously been used in somatic cell nuclear transfer (SCNT) to
improve the cloning efficiency in several species, which led our team to investigate the …

Insufficient epigenetic reprogramming of donor nuclei is believed to be one of the most
important causes of low development efficiency of mammalian somatic cell nuclear transfer …

The first successful rabbit SCNT was achieved more than one decade ago, yet rabbits
remain one of the most difficult species to clone. The present study was designed to …

Our group and others have found that the treatment of embryos with trichostatin A (TSA) after
cloning by somatic cell nuclear transfer (SCNT) results in a significant improvement in …

Objective Nuclear transfer-embryonic stem cells (NT-ESCs) are genetically identical to the
donor's cells; provide a renewable source of tissue for replacement, and therefore, decrease …

The low success rate of animal cloning by somatic cell nuclear transfer (SCNT) is believed to
be associated with epigenetic errors including abnormal DNA hypermethylation. Recently …

The present study was carried out to examine the effects of post‐activation treatment of
trichostatin A (TSA), a histone deacetylase inhibitor, on in vitro development and transgene …