Although the success rate of sheep cloning remains extremely low, using a histone
deacetylase (HDAC) inhibitor to increase histone acetylation in SCNT embryos has …

This study aimed to determine the acetylation at lysine 9/18/23 of histone H3
(H3K9ac/H3K18ac/H3K23ac; H3K9/18/23 ac) and the di‐methylation at lysine 9 of histone …

Limited success of somatic cell nuclear transfer is attributed to incomplete reprogramming of
transferred nuclei. The objective was to determine if 5-aza-2′-deoxycytidine (5-aza-dC) …

The epigenetic status of a donor nucleus is important on the developmental ability of
embryos produced by somatic cell nuclear transfer (SCNT). The low success rate of animal …

Department of Reproductive Biotechnology and Cryoconservation, National Research
Institute of Animal Production, 32-083 Balice n. Kraków, Poland♦ Corresponding author …

To facilitate nuclear reprogramming, somatic cells or somatic cell nuclear-transferred
(SCNT) oocytes have been treated with the histone deacetylase inhibitor trichostatin A …

Developmental defects in somatic cell nuclear transfer (SCNT) embryos are principally
attributable to incomplete epigenetic reprogramming. Small-molecule inhibitors such as …

The poor efficiency of animal cloning is mainly attributed to the defects in epigenetic
reprogramming of donor cells' chromatins during early embryonic development. Previous …

The purpose of this study was to investigate the effects of the histone deacetylase (HDAC)
inhibitor trichostatin A (TSA) on transgene expression and development of porcine …