In mammalian cloning by somatic cell nuclear transfer (SCNT), the treatment of
reconstructed embryos with histone deacetylase (HDAC) inhibitors improves efficiency. So …

Transgenes integrated into mammalian cells are silenced rapidly. This phenomenon
correlates with repressed chromatin structure marked by histone hypoacetylation. This study …

Although mammalian cloning by somatic cell nuclear transfer (SCNT) has been established
in various species, the low developmental efficiency has hampered its practical applications …

The present study was designed to examine the effect of trichostatin A (TSA, a histone
deacetylase inhibitor) treatment on in vitro developmental ability of pig cloned embryos and …

Reprogramming of differentiated nuclei into a totipotent embryonic state following somatic
cell nuclear transfer (SCNT) is not efficient. Previous studies in the hybrid B6D2F1 mouse …

We investigated the effects of exposure time and concentration of trichostatin A (TSA) on in
vitro development and quality of bovine SCNT embryos. At multiple time points, the relative …

The present study assessed changes in epigenetic markers and pre-and postimplantation
development in somatic cell nuclear transfer (SCNT) porcine embryos after treatment with …

The NIH miniature pig was developed specifically for xenotransplantation and has been
extensively used as a large animal model in many other biomedical experiments. However …

Abstract The National Institutes of Health (NIH) miniature pig was developed specifically for
xenotransplantation and has been extensively used as a large-animal model in many other …

Reprogramming impairment of DNA methylation may be partly responsible for the low
efficiency in somatic cell nuclear transfer. In this study, bovine fibroblast cells were …