We previously reported that treatment of both donor cells and early cloned embryos with a
combination of 0.01 μM 5-aza-2/-Deoxycytidine (5-aza-dC) and 0.05 μM trichostatin A (TSA) …

Since 1996, when Dolly was born, cloned vertebrates have been produced in many species.
However, the success rate of animal cloning has remained very low especially in mice. This …

Since the first cloned mammal, Dolly the sheep, the success rates of somatic cell nuclear
transfer (SCNT) have been extremely low. This inefficiency has been limiting practical …

The aim of the present study was to examine the effects of CUDC-101, a novel histone
deacetylase inhibitor, on the in vitro development and expression of the epigenetic marker …

Since the birth of Cumulina, the first mouse clone produced by somatic cell nuclear transfer
(SCNT), the success rate of cloning in mice has been extremely low compared with other …

We previously found that treatment of both donor cells and early cloned embryos with
combination of 5-aza-2′-deoxycytidine (5-aza-dC) and trichostatin A (TSA) significantly …

Trichostatin A (TSA), a histone deacetylase inhibitor, is a known teratogen causing
malformations such as vertebral fusions when applied during the postimplantation period; …

In this study, we investigated the effects of the histone deacetylase inhibitor PXD101
(belinostat) on the preimplantation development of porcine somatic cell nuclear transfer …

Trichostain A (TSA), an inhibitor of histone deacetylases, improved developmental
competence of SCNT embryos in many species, apparently by improved epigenetic …

The objective was to determine the effects of trichostatin A (TSA), a potent histone
deacetylase inhibitor, on eight-cell bovine embryos. That treatment increased histone …