Abstract Development to blastocyst following nuclear transfer is dependent on the donor
cell's ability to reprogram its genome to that of a zygote. This reprogramming step is …

Our group found that the treatment of embryos with histone deacetylase inhibitors (HDACi),
including trichostatin A, Scriptaid, suberoylanilide hydroxamic acid, and oxamflatin, after …

Trichostatin A is histone deacetylase inhibitor (HDACi)(Turner, 2000), which is known to be
a critical factor for successful reprogramming during SCNT (Armstrong et al., 2006). Histone …

Introduction and aims Although, it has been success in the generation of animal clones from
somatic cells in various animal species, the information related to nuclear reprogramming of …

Epigenetic status of the genome of a donor nucleus has an important effect on the
developmental potential of cloned embryos produced by somatic cell nuclear transfer …

The objective was to determine the effects of ascorbic acid (AA), trichostatin A (TSA), and
their combined treatment (TA) on reprogramming and development of cloned porcine …

Histone deacetylation occurs upon the transfer of somatic nuclei into enucleated oocytes,
but its role in reprogramming somatic chromatin to the totipotent state is unknown. To …

Somatic cell nuclear transfer (SCNT) has shown tremendous potential for understanding the
mechanisms of reprogramming and creating applications in the realms of agriculture …

Recently, the modification of the epigenetic status of somatic cell nuclear transfer (SCNT)
embryos by treatment with histone deacetylase inhibitors (HDACis) has made it possible to …

Somatic cell nuclear transfer technique increased expectations among many for its potential
to advance the regenerative therapy field. Cloned embryos, however, exhibit several …