Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies
Abstract Background Malaria caused by Plasmodium falciparum can result in several
different syndromes with severe clinical consequences for the about 200 million individuals …
different syndromes with severe clinical consequences for the about 200 million individuals …
Induction of Adhesion-Inhibitory Antibodies against Placental Plasmodium falciparum Parasites by Using Single Domains of VAR2CSA
MA Nielsen, VV Pinto, M Resende… - Infection and …, 2009 - Am Soc Microbiol
In areas of endemicity pregnancy-associated malaria is an important cause of maternal
anemia, stillbirth, and delivery of low-birth-weight children. The syndrome is precipitated by …
anemia, stillbirth, and delivery of low-birth-weight children. The syndrome is precipitated by …
[HTML][HTML] Differential adhesion-inhibitory patterns of antibodies raised against two major variants of the NTS-DBL2X region of VAR2CSA
J Doritchamou, P Bigey, MA Nielsen, S Gnidehou… - Vaccine, 2013 - Elsevier
Background VAR2CSA is a large polymorphic Plasmodium falciparum protein expressed on
infected erythrocytes (IE) that allows their binding in the placenta, thus precipitating …
infected erythrocytes (IE) that allows their binding in the placenta, thus precipitating …
Identification of VAR2CSA domain-specific inhibitory antibodies of the Plasmodium falciparum erythrocyte membrane protein 1 using a novel flow cytometry assay
H Obiakor, M Avril, NJ MacDonald… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
ABSTRACT VAR2CSA, a member of the Plasmodium falciparum erythrocyte membrane
protein 1 (PfEMP1) family, is a leading candidate for use in vaccines to protect first-time …
protein 1 (PfEMP1) family, is a leading candidate for use in vaccines to protect first-time …
Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites
P Fernandez, NK Viebig, S Dechavanne, C Lépolard… - Malaria Journal, 2008 - Springer
Background Pregnancy-associated malaria (PAM) is a serious consequence of Plasmodium
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …
Identification and characterization of B-cell epitopes in the DBL4ε domain of VAR2CSA
SB Ditlev, MA Nielsen, M Resende, MØ Agerbæk… - 2012 - journals.plos.org
Malaria during pregnancy in Plasmodium falciparum endemic regions is a major cause of
mortality and severe morbidity. VAR2CSA is the parasite ligand responsible for …
mortality and severe morbidity. VAR2CSA is the parasite ligand responsible for …
Identification of Id1-DBL2X of VAR2CSA as a key domain inducing highly inhibitory and cross-reactive antibodies
B Bordbar, N Tuikue-Ndam, P Bigey, J Doritchamou… - Vaccine, 2012 - Elsevier
PURPOSE OF THE RESEARCH: VAR2CSA is considered as the main target of protective
immunity against pregnancy-associated malaria. VAR2CSA high molecular weight …
immunity against pregnancy-associated malaria. VAR2CSA high molecular weight …
[HTML][HTML] Designing a VAR2CSA-based vaccine to prevent placental malaria
M Fried, PE Duffy - Vaccine, 2015 - Elsevier
Placental malaria (PM) due to Plasmodium falciparum is a major cause of maternal, fetal
and infant mortality, but the mechanisms of pathogenesis and protective immunity are …
and infant mortality, but the mechanisms of pathogenesis and protective immunity are …
Strain-Transcendent Immune Response to Recombinant Var2CSA DBL5-ε Domain Block P. falciparum Adhesion to Placenta-Derived BeWo Cells under Flow …
Background Pregnancy-associated malaria (PAM) is a serious consequence of the
adhesion to the placental receptor chondroitin sulfate A (CSA) of Plasmodium falciparum …
adhesion to the placental receptor chondroitin sulfate A (CSA) of Plasmodium falciparum …
Identification of Plasmodium falciparum var1CSA and var2CSA domains that bind IgM natural antibodies
JP Semblat, A Raza, SA Kyes, JA Rowe - Molecular and biochemical …, 2006 - Elsevier
Malaria in pregnancy is responsible for maternal anaemia, low-birth-weight babies and
infant deaths. Plasmodium falciparum infected erythrocytes are thought to cause placental …
infant deaths. Plasmodium falciparum infected erythrocytes are thought to cause placental …