Background Alzheimer's disease (AD) is a neurodegenerative dementia characterized by
the decline of cognition and the presence of neuropathological changes including neuronal …

Alzheimer's disease (AD) is an age-related dementia, characterized by amyloid plaques,
neurofibrillary tangles, neuroinflammation, and neuronal loss in the brain. Components of …

J. Neurochem.(2010) 113, 389–401. Abstract Alzheimer's disease (AD), a progressive
neurodegenerative disease characterized by the accumulation of amyloid‐β protein and …

Multiple studies have recognized the involvement of the complement cascade during
Alzheimer's disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the …

There is evidence that the complement system, a major component of inflammatory
responses, may play an important role in neurodegenerative conditions such as Alzheimer's …

In our earlier results, we demonstrated that cells expressing the complement C5aR are
vulnerable since abnormal activation of C5aR caused apoptosis of these cells. In this study …

Background Alzheimer's disease (AD) is the most common neurodegenerative disease
characterized by neuronal loss due to amyloid beta aggregations, neurofibrillary tangles …

Alzheimer's disease (AD) brains contain large numbers of amyloid-β peptide (Aβ) deposits
associated with activated microglia, astrocytes and dystrophic neurites. Activated …

The complement system is part of the innate immune system that comprises several small
proteins activated by sequential cleavages. The majority of these complement components …

Objective: The dysregulation of neuro-inflammation is one of the attributes of the
pathogenesis of Alzheimer's disease (AD). Over-expression of complement proteins co …