PTEN function in normal and neoplastic growth
LML Chow, SJ Baker - Cancer letters, 2006 - Elsevier
The PTEN tumor suppressor is a central negative regulator of the PI3K/AKT signaling
cascade that influences multiple cellular functions including cell growth, survival …
cascade that influences multiple cellular functions including cell growth, survival …
[HTML][HTML] PTEN: multiple functions in human malignant tumors
M Milella, I Falcone, F Conciatori, U Cesta Incani… - Frontiers in …, 2015 - frontiersin.org
PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …
Human cancer, PTEN and the PI-3 kinase pathway
R Parsons - Seminars in cell & developmental biology, 2004 - Elsevier
The PI-3 kinase pathway is a major driving force for human cancer. One common way of
stimulating the PI-3 kinase pathway occurs through inactivation of the PTEN tumor …
stimulating the PI-3 kinase pathway occurs through inactivation of the PTEN tumor …
[HTML][HTML] Tenets of PTEN tumor suppression
Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23
locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor …
locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor …
Mechanisms of PTEN loss in cancer: It's all about diversity
V Álvarez-Garcia, Y Tawil, HM Wise… - Seminars in cancer biology, 2019 - Elsevier
PTEN is a phosphatase which metabolises PIP 3, the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
The role of PTEN signaling perturbations in cancer and in targeted therapy
M Keniry, R Parsons - Oncogene, 2008 - nature.com
The PTEN tumor suppressor was discovered by its homozygous deletion and other
mutations in cancer. Since then, PTEN has been shown to be a non-redundant …
mutations in cancer. Since then, PTEN has been shown to be a non-redundant …
The functions and regulation of the PTEN tumour suppressor: new modes and prospects
PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
PTEN: from pathology to biology
ML Sulis, R Parsons - Trends in cell biology, 2003 - cell.com
The PTEN tumour suppressor gene is mutated frequently in many malignancies and its
importance in the development of cancer is probably underestimated. As the primary …
importance in the development of cancer is probably underestimated. As the primary …
The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway
I Sansal, WR Sellers - Journal of clinical oncology, 2004 - ascopubs.org
Genetic alterations targeting the PTEN tumor suppressor gene are among the most
frequently noted somatic mutations in human cancers. Such lesions have been noted in …
frequently noted somatic mutations in human cancers. Such lesions have been noted in …
PTEN signaling in brain: neuropathology and tumorigenesis
R Endersby, SJ Baker - Oncogene, 2008 - nature.com
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor
that antagonizes the phosphatidylinositol-3-kinase (PI3K)/Akt/mTOR pathway by functioning …
that antagonizes the phosphatidylinositol-3-kinase (PI3K)/Akt/mTOR pathway by functioning …