The PTEN tumor suppressor is a central negative regulator of the PI3K/AKT signaling
cascade that influences multiple cellular functions including cell growth, survival …

PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …

The PI-3 kinase pathway is a major driving force for human cancer. One common way of
stimulating the PI-3 kinase pathway occurs through inactivation of the PTEN tumor …

Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23
locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor …

PTEN is a phosphatase which metabolises PIP 3, the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …

The PTEN tumor suppressor was discovered by its homozygous deletion and other
mutations in cancer. Since then, PTEN has been shown to be a non-redundant …

PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …

The PTEN tumour suppressor gene is mutated frequently in many malignancies and its
importance in the development of cancer is probably underestimated. As the primary …

Genetic alterations targeting the PTEN tumor suppressor gene are among the most
frequently noted somatic mutations in human cancers. Such lesions have been noted in …

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor
that antagonizes the phosphatidylinositol-3-kinase (PI3K)/Akt/mTOR pathway by functioning …