Concomitant administration of grapefruit juice can increase the plasma concentration of
numerous drugs in humans and decrease the concentration of a few others. Such elevations …

Grapefruit juice can markedly augment oral drug bioavailability was originally based on an
unexpected observation from an interaction study between the dihydropyridine calcium …

Concomitant intake with grapefruit juice increases the concentrations of many drugs in
humans. The effect seems to be mediated mainly by suppression of the cytochrome P450 …

Some drugs demonstrate a significantly greater (up to 3-fold) mean oral bioavailability on
coadministration with grapefruit juice. With some calcium antagonists, the benzodiazepines …

More than a decade has passed since it was unintentionally discovered that grapefruit juice
interacts with certain drugs. The coadministration of these drugs with grapefruit juice can …

A single glass of grapefruit juice can improve the oral bioavailability of a drug thus either
increasing its efficacy or enhancing its adverse effects particularly if the therapeutic index is …

CME sequently, CYP3A4 activity in the small intestine is impaired until de novo synthesis
returns the enzyme to its previous level. This mechanism explains the important clinical …

The novel finding that grapefruit juice can markedly augment oral drug bioavailability was
based on an unexpected observation from an interaction study between the dihydropyridine …

The novel finding that grapefruit juice can markedly augment oral drug bioavailability was
based on an unexpected observation from an interaction study between the dihydropyridine …

It is well known that intake of grapefruit juice affects the pharmacokinetics of various kinds of
drugs. It has been reported that other citrus juices also interact with certain drugs. To re …