Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology

D Dobrev, J Heijman, R Hiram, N Li… - Nature Reviews …, 2023 - nature.com
Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …

Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation

C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …

[HTML][HTML] Cardiomyocyte inflammasome signaling in cardiomyopathies and atrial fibrillation: mechanisms and potential therapeutic implications

G Chen, MG Chelu, D Dobrev, N Li - Frontiers in physiology, 2018 - frontiersin.org
Inflammasomes are high molecular weight protein complexes in the cytosol of immune and
other cells that play a critical role in the innate immune system in response to cellular stress …

Inflammasomes and proteostasis novel molecular mechanisms associated with atrial fibrillation

N Li, BJJM Brundel - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF), the most common progressive and age-related cardiac arrhythmia,
affects millions of people worldwide. AF is associated with common risk factors, including …

Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review

A Ajoolabady, S Nattel, GYH Lip, J Ren - Journal of the American College …, 2022 - jacc.org
As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …

Role of inflammation in atrial fibrillation pathophysiology and management

M Harada, DR Van Wagoner, S Nattel - Circulation journal, 2015 - jstage.jst.go.jp
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia, but the methods
available for treating AF and its complications (of which the most important is …

[HTML][HTML] Evidence for inflammation as a driver of atrial fibrillation

X Zhou, SC Dudley Jr - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Atrial fibrillation (AF) is one of the most common types of arrhythmias and increases
cardiovascular morbidity and mortality. Current therapeutic approaches to AF that focus on …

Implications of inflammation and fibrosis in atrial fibrillation pathophysiology

M Harada, S Nattel - Cardiac Electrophysiology Clinics, 2021 - cardiacep.theclinics.com
Inflammation has been implicated in the pathophysiology of atrial fibrillation (AF) and
mediates various pathologic processes such as oxidative stress and apoptosis. Atrial fibrosis …

Inflammation and the pathogenesis of atrial fibrillation

YF Hu, YJ Chen, YJ Lin, SA Chen - Nature Reviews Cardiology, 2015 - nature.com
Atrial fibrillation (AF) is the most common cardiac arrhythmia. However, the development of
preventative therapies for AF has been disappointing. The infiltration of immune cells and …

Role of inflammatory signaling in atrial fibrillation

L Scott Jr, N Li, D Dobrev - International journal of cardiology, 2019 - Elsevier
Atrial fibrillation (AF), the most prevalent arrhythmia, is often associated with enhanced
inflammatory response. Emerging evidence points to a causal role of inflammatory signaling …