Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology
Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …
Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation
C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
[HTML][HTML] Cardiomyocyte inflammasome signaling in cardiomyopathies and atrial fibrillation: mechanisms and potential therapeutic implications
Inflammasomes are high molecular weight protein complexes in the cytosol of immune and
other cells that play a critical role in the innate immune system in response to cellular stress …
other cells that play a critical role in the innate immune system in response to cellular stress …
Inflammasomes and proteostasis novel molecular mechanisms associated with atrial fibrillation
N Li, BJJM Brundel - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF), the most common progressive and age-related cardiac arrhythmia,
affects millions of people worldwide. AF is associated with common risk factors, including …
affects millions of people worldwide. AF is associated with common risk factors, including …
Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review
As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …
Role of inflammation in atrial fibrillation pathophysiology and management
M Harada, DR Van Wagoner, S Nattel - Circulation journal, 2015 - jstage.jst.go.jp
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia, but the methods
available for treating AF and its complications (of which the most important is …
available for treating AF and its complications (of which the most important is …
[HTML][HTML] Evidence for inflammation as a driver of atrial fibrillation
X Zhou, SC Dudley Jr - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Atrial fibrillation (AF) is one of the most common types of arrhythmias and increases
cardiovascular morbidity and mortality. Current therapeutic approaches to AF that focus on …
cardiovascular morbidity and mortality. Current therapeutic approaches to AF that focus on …
Implications of inflammation and fibrosis in atrial fibrillation pathophysiology
M Harada, S Nattel - Cardiac Electrophysiology Clinics, 2021 - cardiacep.theclinics.com
Inflammation has been implicated in the pathophysiology of atrial fibrillation (AF) and
mediates various pathologic processes such as oxidative stress and apoptosis. Atrial fibrosis …
mediates various pathologic processes such as oxidative stress and apoptosis. Atrial fibrosis …
Inflammation and the pathogenesis of atrial fibrillation
YF Hu, YJ Chen, YJ Lin, SA Chen - Nature Reviews Cardiology, 2015 - nature.com
Atrial fibrillation (AF) is the most common cardiac arrhythmia. However, the development of
preventative therapies for AF has been disappointing. The infiltration of immune cells and …
preventative therapies for AF has been disappointing. The infiltration of immune cells and …
Role of inflammatory signaling in atrial fibrillation
Atrial fibrillation (AF), the most prevalent arrhythmia, is often associated with enhanced
inflammatory response. Emerging evidence points to a causal role of inflammatory signaling …
inflammatory response. Emerging evidence points to a causal role of inflammatory signaling …