In recent times, search for potent and highly selective thrombolytic agents with minimal side
effects has become a major area of research. The aim of the present study was to develop …

Streptokinase is one of the most commonly used thrombolytic agents for the treatment of
thromboembolism. Short half-life of the streptokinase requires administration of higher dose …

The present study was aimed to study the effect of RGD peptide conjugation on the bio-
distribution behaviour of long circulatory liposomes in the thrombosed rat model. Further …

Several plasminogen activators (PAs) have been found effective in treating different
thromboembolic diseases. However, administration of conventional thrombolytic therapy is …

Background: Targeted delivery of antithrombotic (thrombolytic) drugs is expected to increase
their efficacy and decrease side effects, especially in the case of thrombolytic enzymes …

Background: Clinical efficacy of thrombolytic drugs is limited by lack of specific delivery and
requires large therapeutic doses which increase toxicity. Encapsulating these drugs in …

Vascular diseases leading to thrombo-occlusion are the leading cause of morbidity and
mortality worldwide. Revascularization and restoration of antegrade blood flow is critical for …

In this study, a method was developed for the efficient entrapment of active tissue-type
Plasminogen Activator (t-PA) into liposomes. Experimental conditions were varied to …

Thrombosis, a critical event in blood vessels, not only is associated with myocardial
infarction and stroke, but also accounts for considerable morbidity and mortality …

It remains a major challenge to develop a selective and effective fibrinolytic system for
thrombolysis with minimal undesirable side effects. Herein, we report a multifunctional …