Mesenchymal stem cells ameliorate experimental arthritis via expression of interleukin-1 receptor antagonist

K Lee, N Park, H Jung, YA Rim, Y Nam, J Lee, SH Park… - PloS one, 2018 - journals.plos.org
Human bone marrow-derived mesenchymal stem cells (MSCs) have been observed to
inhibit arthritis in experimental animal models such as collagen-induced arthritis. However …

Immunosuppressive effects of mesenchymal stem cells in collagen-induced mouse arthritis

F Mao, WR Xu, H Qian, W Zhu, YM Yan, QX Shao… - Inflammation …, 2010 - Springer
Objective The objective of this study was to investigate the efficacy of mesenchymal stem
cell (MSC) in the treatment of arthritis. Methods Mesenchymal stem cells were injected …

Intraperitoneal infusion of mesenchymal stem cell attenuates severity of collagen antibody induced arthritis

Y Nam, SM Jung, YA Rim, H Jung, K Lee, N Park… - PLoS …, 2018 - journals.plos.org
It is unclear how systemic administration of mesenchymal stem cells (MSCs) controls local
inflammation. The aim of this study was to evaluate the therapeutic effects of human MSCs …

Mesenchymal stem cells overexpressing interleukin-10 attenuate collagen-induced arthritis in mice

JJ Choi, SA Yoo, SJ Park, YJ Kang… - Clinical & …, 2008 - academic.oup.com
Mesenchymal stem cells (MSCs) have the inherent ability to migrate to multiple organs and
to exert immunosuppressive activity. The aim of this study was to investigate the anti …

Bone marrow–derived and synovium‐derived mesenchymal cells promote Th17 cell expansion and activation through caspase 1 activation: Contribution to the …

A Eljaafari, ML Tartelin, H Aissaoui… - Arthritis & …, 2012 - Wiley Online Library
Objective Th17 cells have been implicated in rheumatoid arthritis (RA). We hypothesized
that the interaction of T cells with bone marrow–derived mesenchymal stem cells (BM …

Mesenchymal stem cells from patients with rheumatoid arthritis display impaired function in inhibiting Th17 cells

Y Sun, W Deng, L Geng, L Zhang, R Liu… - Journal of …, 2015 - Wiley Online Library
Mesenchymal stem cells (MSCs) possess multipotent and immunomodulatory properties
and are suggested to be involved in the pathogenesis of immune‐related diseases. This …

Treatment of collagen-induced arthritis using immune modulatory properties of human mesenchymal stem cells

KH Park, CH Mun, MI Kang, SW Lee… - Cell …, 2016 - journals.sagepub.com
Mesenchymal stem cells (MSCs) have immune modulatory properties. We investigated the
potential therapeutic effects of human bone marrow (BM)-, adipose tissue (AD)-, and cord …

[HTML][HTML] Combination therapy of mesenchymal stromal cells and interleukin-4 attenuates rheumatoid arthritis in a collagen-induced murine model

SM Haikal, NF Abdeltawab, LA Rashed, TI Abd El-Galil… - Cells, 2019 - mdpi.com
Rheumatoid arthritis (RA) is a disease of the joints that causes decreased quality of life.
Mesenchymal stromal cells (MSCs) have immunosuppressive properties, with possible use …

Transforming growth factor β–transduced mesenchymal stem cells ameliorate experimental autoimmune arthritis through reciprocal regulation of Treg/Th17 cells and …

MJ Park, HS Park, ML Cho, HJ Oh, YG Cho… - Arthritis & …, 2011 - Wiley Online Library
Objective Bone marrow–derived mesenchymal stem cells (MSCs) can prevent various
autoimmune diseases. We examined the therapeutic potential of transforming growth factor …

Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen‐induced arthritis

A Augello, R Tasso, SM Negrini… - Arthritis & …, 2007 - Wiley Online Library
Abstract Objective Mesenchymal stem cells (MSCs) are precursors of tissue of mesenchymal
origin, but they also have the capacity to regulate the immune response by suppressing T …