Selective antagonism of capsaicin by capsazepine: evidence for a spinal receptor site in capsaicin‐induced antinociception
AH Dickenson, A Dray - British journal of pharmacology, 1991 - Wiley Online Library
1 Capsazepine has recently been described as a competitive capsaicin antagonist. We have
used this compound to test the hypotheses that the in vitro and in vivo effects of capsaicin …
used this compound to test the hypotheses that the in vitro and in vivo effects of capsaicin …
Capsazepine reversal of the antinociceptive action of capsaicin in vivo.
MN Perkins, EA Campbell - British journal of pharmacology, 1992 - ncbi.nlm.nih.gov
This study was designed to investigate the antinociceptive activity of capsaicin in acute and
persistent nocifensor behavioural models and to determine whether this was mediated via a …
persistent nocifensor behavioural models and to determine whether this was mediated via a …
Neuropharmacological mechanisms of capsaicin and related substances.
A Dray - Biochemical pharmacology, 1992 - europepmc.org
Capsaicin activates poorly myelinated primary afferent neurons, many of which are
polymodal nociceptors. Activation is accompanied by membrane depolarization and the …
polymodal nociceptors. Activation is accompanied by membrane depolarization and the …
Actions of capsaicin on peripheral nociceptors of the neonatal rat spinal cord‐tail in vitro: dependence of extracellular ions and independence of second messengers
A Dray, J Bettaney, P Forster - British journal of pharmacology, 1990 - Wiley Online Library
1 We have tested the hypothesis that capsaicin‐induced activation, desensitization and
impairment of peripheral nociceptor function is mediated by separate mechanisms. This was …
impairment of peripheral nociceptor function is mediated by separate mechanisms. This was …
Mechanism of action of capsaicin-like molecules on sensory neurons
A Dray - Life sciences, 1992 - Elsevier
Capsaicin produces pain by selectively activating polymodal nociceptive neurons. This
involves a membrane depolarization and the opening of a unique, cation-selective, ion …
involves a membrane depolarization and the opening of a unique, cation-selective, ion …
Capsazepine, a novel capsaicin antagonist, selectively antagonises the effects of capsaicin in the mouse spinal cord in vitro
L Urban, A Dray - Neuroscience letters, 1991 - Elsevier
The mouse hemisected spinal cord with attached dorsal roots and spinal ganglia in vitro
preparation was used to investigate the effects of the capsaicin antagonist, capsazepine (2 …
preparation was used to investigate the effects of the capsaicin antagonist, capsazepine (2 …
Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin
1 Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, capsaicin. The
present study shows the capsazepine acts as a competitive antagonist of capsaicin. 2 …
present study shows the capsazepine acts as a competitive antagonist of capsaicin. 2 …
A spinal mechanism of action is involved in the antinociception produced by the capsaicin analogue NE 19550 (olvanil)
A Dickenson, C Hughes, A Rueff, A Dray - Pain, 1990 - journals.lww.com
We have studied the effect of NE 19550 (olvanil, N-(4-hydroxy-3-methoxyphenyl) methyl-9Z-
octadecenamide), a capsaicin analogue with approximately equipotent antinociceptive …
octadecenamide), a capsaicin analogue with approximately equipotent antinociceptive …
Capsaicin desensitization of peripheral nociceptive fibres does not impair sensitivity to other noxious stimuli
A Dray, J Bettaney, P Forster - Neuroscience letters, 1989 - Elsevier
Capsaicin was tested on peripheral fibres in vitro to determine whether evoked
depolarization or desensitization were likely to explain the antinociception observed after …
depolarization or desensitization were likely to explain the antinociception observed after …
[PDF][PDF] Capsaicin and pain mechanisms.
Capsaicin, the active ingredient in hot chilli peppers, has selective actions on unmyelinated
C-fibres and thinly myelinated A primary sensory neurones [37, 100](Table 1). Most …
C-fibres and thinly myelinated A primary sensory neurones [37, 100](Table 1). Most …