Capsaicin depolarizes primary afferent C-fibers releasing substance P (SP) whose N-
terminal metabolites appear to play a role in the development of antinociception. Because …

Actions of capsaicin were examined on synaptic transmissions in the substantia gelatinosa
(SG) of adult rat spinal cord slices using the whole-cell patch-recording technique. Bath …

Glutamate (Glu) is involved in excitatory neurotransmission and nociception and plays an
essential role in relaying noxious stimuli in the spinal cord. Intrathecal or epidural injection of …

Desensitization of sensory afferents with topical capsaicin has been employed to treat a
variety of neuropathic disorders in humans, however, few studies have been undertaken to …

Capsaicin applied to the soma of fast and slow conducting primary afferent fibers had a
depolarizing action associated with an increase in membrane conductance. The …

Acute capsaicin treatment in adult rats has been shown to increase firing rates in peripheral
sensory nerves involved in the transmission of nociceptive input due to chemical irritants or …

A series of compounds incorporating replacements for theamide bond “B-region” moiety of
capsaicin have been synthesized, including vanillylamides and esters, homovanillic acid …

Capsaicin, 8-methyl-N-vanillyl-6-nonenamide, is the pungent algesic substance of the red
pepper. On local or systemic injection capsaicin causes a marked stimulation of peripheral …

A preparation of the hindpaw-skin together with the saphenous nerve from the adult rat was
maintained in vitro. This was used to characterize the properties of sensory receptors with …

Cutaneous sensibility and neurogenic vasodilatation (flare) were measured before, during
and after long-term topical application of capsaicin in humans. Each subject applied a …