BACKGROUND: The expression of the multidrug resistance-1 (MDR-1) gene which encodes
p-glycoprotein, is recognized as a biological mechanism possibly contributing to treatment …

Acute myeloid leukemia (AML) has a poor long-term prognosis, with a disease-free survival
rate of only 20%. Drug resistance remains the major obstacle in this disease, although …

The Multidrug Resistance gene (MDR 1) is frequently expressed in acute myeloid leukaemia
(AML). MDR 1 is associated with resistance to chemotherapy in vitro and with a poor …

The authors established a highly sensitive, specific and quantitative method-RT-PCR for
measuring the levels of MDR1 mRNA in 91 acute leukemic samples (including 30 untreated …

Methods The expression of multidrug resistance gene (mdr1) mRNA was measured in 85
patients with acute leukemia and in 20 normal controls by using reverse transcription …

Background: The most important mechanism of drug resistance is related to the over-
expression of P-glycoprotein which is encoded by the MDR1 gene. The expression of MDR1 …

Background Despite the advances in the cure rate for acute myeloid leukemia (AML), a
considerable number of patients die from the disease due to the occurrence of multidrug …

To evaluate the frequency and the prognostic value of different mechanisms of drug
resistance in acute leukemias, we investigated the expression of mdr 1 by …

Resistance to multiple chemotherapeutic agents is related to the production of P-
glycoprotein, a transmembrane drug efflux pump that is encoded by the multidrug resistance …

We have compared the prognostic value of MDR1 RNA expression with that of other clinical
parameters in 63 patients with acute myeloid leukemia. MDR1 RNA expression of the …