Resistance to cytotoxic agents may be encountered during the treatment of acute
myeloblastic leukaemia (AML). P-glycoprotein encoded by the MDR-1 gene has been …

The clinical significance of the multidrug resistance (MDR 1) gene phenotype was
investigated in newly diagnosed AML and was compared with other clinical and biological …

BACKGROUND: Multi-drug resistance (MDR) is one of the most important obstacles in the
chemotherapy of acute leukemia, so the modulators of MDR have been developed and tried …

6550 Background: Multidrug resistance (MDR) is one of the important mechanisms of
treatment failure of acute myeloid leukemia (AML). Recently, MDR-1 gene single nucleotide …

Resistance to chemotherapy is one of the major obstacles to effective treatment in acute
myeloid leukemia (AML). The most extensively studied protein involved in multidrug …

Expression of the multi-drug-resistance (MDR) protein gpl70 encoded by the mdrl gene has
been implied to play a role in acute myeloid leukemia (AML) refractory to chemotherapy. We …

White blood cells from a total of 19 patients diagnosed as having acute lymphoblastic (ALL)
or acute myeloid (AML) leukaemia were analysed (36 samples) for amplification and …

Objective To assess the correlation of the multidrug resistance-1 (MDR1) gene single
nucleotide polymorphisms (SNP) C1236T, G2677T/A and C3435T with the outcome of …

Up till now, clinical data on the possible prognostic influence of multidrug resistance (MDR)
in hematological malignancies have been inconsistent, probably due to technical pitfalls …

Background: Multidrug resistance is caused by overexpression of P-glycoprotein (P-gp,
encoded by the mdrl gene), a transmembrane energy-dependent efflux pump which acts by …