Bone marrow specimens from 100 cases of acute leukemia (AL) diagnosed by MIC were
detected with fluorescence microscopy for their mdr-1 expression using monoclonal …

Abstract Abstract 4677 Introdution The expression of CD56 antigen and over-expression of
the multidrug resistance gene 1 (MDR1) seems to confer the poor therapeutic outcome to …

The expression of P-glycoprotein (P-gp), encoded by the MDR 1 gene, is an independent
adverse prognostic factor for response and survival in de novo acute myeloid leukemia …

BACKGROUND: The expression of multi-drug resistance (MDR) in acute leukemia was
known to decrease the outcome of chemotherapy and to increase the rate of relapse. Of the …

We have analysed and compared the applicability of mRNA quantitation and
immunocytochemistry to the detection of the multidrug resistant gene mdr 1 and its protein …

MDR1 gene expression was examined in acute leukemia cells from 75 Japanese patients at
diagnosis (50 with acute myeloblastic leukemia [AML]: 10 M1, 18 M2, 5 M3, 8 M4, 9 M5; 25 …

An important number of patients with Acute Myeloid Leukemia (AML) experience relapse or
resistance to chemotherapy. One of the mechanisms involved in this resistance is the …

Drug resistance in acute myeloid leukaemia (AML) may be caused by overexpression of the
P glycoprotein (PGP), an efflux pump encoded by the multidrug resistance mdr1 gene …

Cytogenetic abnormalities are among the most important factors affecting the outcome of
patients with acute myeloid leukaemia (AML), but approximately 40–50% of AML cases …

Therapeutic resistance is a major obstacle in the treatment of acute myeloid leukemia (AML).
Such resistance has been associated with rapid drug efflux mediated by the multidrug …