Functional multidrug resistance phenotype associated with combined overexpression of Pgp/MDR1 and MRP together with 1-beta-D-arabinofuranosylcytosine …
GJ Schuurhuis, HJ Broxterman, GJ Ossenkoppele… - Clinical cancer research …, 1995 - AACR
Overexpression of P-glycoprotein (Pgp) or MDR1 mRNA has been shown to be a negative
prognostic factor for clinical outcome in acute myeloid leukemia (AML). However, resistance …
prognostic factor for clinical outcome in acute myeloid leukemia (AML). However, resistance …
Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia
T Efferth, A Sauerbrey… - International …, 2003 - spandidos-publications.com
Multidrug resistance is an important mechanism responsible for refractoriness of leukemia
and worse outcome of patients. Overexpression of the multidrug resistance gene, MDR1, is …
and worse outcome of patients. Overexpression of the multidrug resistance gene, MDR1, is …
[引用][C] MDR1 RNA expression is an independent prognostic factor in acute myeloid leukemia.
R Pirker, J Wallner, M Götzl, A Gsur, K Geissler… - Blood, 1992 - europepmc.org
This is a comment on" Multidrug resistance (MDR 1) in leukemia: is it time to test?" Blood.
1992 Jan 15; 79 (2): 295-8. This is a comment on" Clinical significance of multidrug …
1992 Jan 15; 79 (2): 295-8. This is a comment on" Clinical significance of multidrug …
MDR1/P-GP expression as a prognostic factor in acute leukemias
JP Marie, O Legrand - Drug Resistance in Leukemia and Lymphoma III, 1999 - Springer
Abstract P-glycoprotein (P-gp) is often expressed (40–50%) on leukemic cells at diagnosis
in acute myelogenous leukemia (AML), and is even more frequently present after treatment …
in acute myelogenous leukemia (AML), and is even more frequently present after treatment …
Expression of multidrug resistance-associated protein (MRP) and multidrug resistance (MDR1) genes in acute myeloid leukemia.
DC Zhou, R Zittoun, JP Marie - Leukemia, 1995 - europepmc.org
The frequency, prognostic value and interrelation of MRP and MDR1 gene expressions
were investigated by quantitative reverse transcription polymerase chain reaction (RT-PCR) …
were investigated by quantitative reverse transcription polymerase chain reaction (RT-PCR) …
Regulatory polymorphisms of multidrug resistance 1 (MDR1) gene are associated with the development of childhood acute lymphoblastic leukemia
H Hattori, A Suminoe, M Wada, Y Koga, K Kohno… - Leukemia research, 2007 - Elsevier
The aim of this study is to determine whether the polymorphisms of the MDR1 gene are
associated with the development of childhood acute lymphoblastic leukemia (ALL). The …
associated with the development of childhood acute lymphoblastic leukemia (ALL). The …
[引用][C] Development of a highly sensitive multiparameter flow cytometric assay correlating MDR1 expression and function: Clinical application to acute myeloid …
CP Leith, KJ Kopecky, IM Chen, FR Appelbaum… - Drug Resistance in …, 1997
Approaches to detect the drug resistance in acute leukemia
T Funato, M Takeda - Journal of Electrophoresis, 2005 - jstage.jst.go.jp
Resistance to chemotherapy is an obstacle to the successful treatment of acute myeloid
leukemia (AML). Failure of therapeutic treatment may be due to the development of …
leukemia (AML). Failure of therapeutic treatment may be due to the development of …
MDR1 RNA expression as a prognostic factor in acute myeloid leukemia: an update
A Gsur, S Zöchbauer, M Götzl, PA Kyrle… - Leukemia & …, 1993 - Taylor & Francis
In order to confirm our initial report on the negative impact of MDR1 gene expression on the
outcome of de novo acute myeloid leukemia (AML), we present an update of our prospective …
outcome of de novo acute myeloid leukemia (AML), we present an update of our prospective …
A new PCR MIMIC strategy to quantify low mdr1 mRNA levels in drug resistant cell lines and AML blast samples
T Illmer, M Schaich, U Oelschlägel, R Nowak… - Leukemia research, 1999 - Elsevier
Determination of the MDR-phenotype in patients suffering from AML is an important hallmark
of treatment outcome but is often complicated by technical problems in P-gp assessment. A …
of treatment outcome but is often complicated by technical problems in P-gp assessment. A …