Acute myeloid leukemia (AML) is clinically, cytogenetically and molecularly a
heterogeneous disease (Zou, 2007). High risk AML constitutes a biologically distinct subset …

We have analyzed MDR1 gene expression in 69 clinical samples obtained from 64 patients
with leukemic hematologic malignancies by using a competitive reverse transcription …

The phenomenon of multidrug resistance (MDR) is frequently encountered in clinical
situations, and could contribute to the failure of chemotherapy in acute leukemia. Preliminary …

Expression of the MDRI Gene and Treatment Outcome in Acute Nonlymphocytic Leukemia Page
1 Expression of the MDRI Gene and Treatment Outcome in Acute Nonlymphocytic Leukemia R …

Abstract Multidrug resistance gene 1 (MDR1) is known for its involvement in the
detoxification through the active transport of toxic compounds from diverse origins outside …

Multidrug resistance (MDR) is a complex phenomenon that includes the expression of many
different genes regulating drug transport or metabolism, cellular repair or detoxification …

Multidrug resistance represents a form of pleiotropic drug resistance that has a prognostic
value in untreated AML. It may affect the outcome of current chemotherapy protocols …

Background The multidrug resistance (mdr1), multidrug resistance associated protein
(mrp1), and glutathione-s-transferase (gst) π genes have been associated with treatment …

We investigated the cellular drug resistance to aclarubicin (Acla), cytosine arabinoside (Ara‐
C), daunorubicin (Dau), doxorubicin (Dox), etoposide (Etop) and mitoxantrone (Mitox) using …

Multi drug resistance (MDR) is a major obstacle for cancer therapy. The three major
candidates accounting for the development of MDR in acute myeloid leukaemia (AML) are …