The activation of memory CD4+ T cells and CD8+ T cells in patients with multiple sclerosis
Y Okuda, M Okuda, BR Apatoff, DN Posnett - Journal of the neurological …, 2005 - Elsevier
To reevaluate whether an association exists between the clinical course of multiple sclerosis
(MS) and the activation of memory T cells, we investigated the phenotype of T cells in …
(MS) and the activation of memory T cells, we investigated the phenotype of T cells in …
Increase of CD8+ T-effector memory cells in peripheral blood of patients with relapsing–remitting multiple sclerosis compared to healthy controls
KF Haegele, CA Stueckle, JP Malin… - Journal of …, 2007 - Elsevier
CCR7 and CD45RA expression on CD4+ and CD8+ T-cells in blood (PB) of 16 patients with
multiple sclerosis (MS) and 16 healthy controls and cerebrospinal fluid (CSF) of 10 patients …
multiple sclerosis (MS) and 16 healthy controls and cerebrospinal fluid (CSF) of 10 patients …
Memory and naive CD4+ lymphocytes in multiple sclerosis
AM Porrini, D Gambi, G Malatesta - Journal of neurology, 1992 - Springer
Summary Helper-inducer (CD29+ CD4+) and suppressor (CD45RACD4+) T-cells have
been recently renamed as memory and naive T-cells, respectively. We measured cells …
been recently renamed as memory and naive T-cells, respectively. We measured cells …
Decrease of CD4+ CD45+ T-cells in chronic-progressive multiple sclerosis
Circulating lymphocyte subpopulations defined by anti-CD45 and other more common T-cell-
specific monoclonal antibodies were analysed in 77 patients with multiple sclerosis and 38 …
specific monoclonal antibodies were analysed in 77 patients with multiple sclerosis and 38 …
Increased CD8+ central memory T cells in patients with multiple sclerosis
GZ Liu, LB Fang, P Hjelmström… - Multiple Sclerosis …, 2007 - journals.sagepub.com
AT-cell-mediated autoimmune process against central nervous system myelin is believed to
underlie the pathogenesis of multiple sclerosis (MS). Formation of immunological memory is …
underlie the pathogenesis of multiple sclerosis (MS). Formation of immunological memory is …
Reduced Frequency of Memory CD8+ T Lymphocytes in Cerebrospinal Fluid and Blood of Patients with Multiple Sclerosis
A Svenningsson, O Andersen, GK Hansson… - Autoimmunity, 1995 - Taylor & Francis
Three color flow cytometry was used to analyze immunoregulatory lymphocyte subsets in
peripheral blood (PB) and cerebrospinal fluid (CSF) of 21 patients with multiple sclerosis …
peripheral blood (PB) and cerebrospinal fluid (CSF) of 21 patients with multiple sclerosis …
Phenotypic characterization of autoreactive T cells in multiple sclerosis
RB Ratts, NJ Karandikar, RZ Hussain, J Choy… - Journal of …, 2006 - Elsevier
MS has been hypothesized to result from autoreactive T cell responses against myelin
antigens. In this report, we examined myelin-specific CD8 and CD4 T cells for two markers …
antigens. In this report, we examined myelin-specific CD8 and CD4 T cells for two markers …
Alterations in levels of CD28-/CD8+ suppressor cell precursor and CD45RO+/CD4+ memory T lymphocytes in the peripheral blood of multiple sclerosis patients
B Crucian, P Dunne, H Friedman… - Clinical Diagnostic …, 1995 - Am Soc Microbiol
A comprehensive peripheral blood immunophenotype analysis of 16 multiple sclerosis (MS)
patients was performed by three-color flow cytometric analysis, and the results were …
patients was performed by three-color flow cytometric analysis, and the results were …
Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients
M Jacobsen, S Cepok, E Quak, M Happel, R Gaber… - Brain, 2002 - academic.oup.com
Multiple sclerosis is a chronic inflammatory demyelinating disease of the CNS. Although the
aetiology of multiple sclerosis is still unknown, it is widely believed that T cells play a central …
aetiology of multiple sclerosis is still unknown, it is widely believed that T cells play a central …
CSF enrichment of highly differentiated CD8+ T cells in early multiple sclerosis
S Jilek, M Schluep, AO Rossetti, L Guignard… - Clinical …, 2007 - Elsevier
CD8+ T cells may play an important role in multiple sclerosis (MS). Whether these cells
would be involved in early stages of MS is unclear. We enrolled 52 patients with suspected …
would be involved in early stages of MS is unclear. We enrolled 52 patients with suspected …