We focus on the application of constraint-based methodologies and, more specifically, flux
balance analysis in the field of metabolic engineering, and enumerate recent developments …

Recent advances in metabolic flux analysis including genome-scale constraints-based flux
analysis and its applications in metabolic engineering are reviewed. Various computational …

In recent years, a growing number of metabolic engineering strain design techniques have
employed constraint‐based modeling to determine metabolic and regulatory network …

Metabolic engineers modify biological systems through the use of modern molecular biology
tools in order to obtain desired phenotypes. However, due to the extreme complexity and …

Motivation: Computational modeling in metabolic engineering involves the prediction of
genetic manipulations that would lead to optimized microbial strains, maximizing the …

In this chapter, the process for the reconstruction of genome-scale metabolic networks is
described, and some of the main applications of such models are illustrated. The …

Background Computational modeling and analysis of metabolic networks has been
successful in metabolic engineering of microbial strains for valuable biochemical production …

Genome-scale metabolic models are increasingly becoming available for a variety of
microorganisms. This has spurred the development of a wide array of computational tools …

Significant advances in system-level modeling of cellular behavior can be achieved based
on constraints derived from genomic information and on optimality hypotheses. For steady …

Genome-scale metabolic network reconstructions in microorganisms have been formulated
and studied for about 8 years. The constraint-based approach has shown great promise in …