Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates
M Avril, MJ Hathaway, A Srivastava, S Dechavanne… - PloS one, 2011 - journals.plos.org
The high molecular weight, multidomain VAR2CSA protein mediating adhesion of
Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a …
Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a …
Identification of Multiple Chondroitin Sulfate A (CSA)–Binding Domains in the var2CSA Gene Transcribed in CSA-Binding Parasites
B Gamain, AR Trimnell, C Scheidig… - The Journal of …, 2005 - academic.oup.com
Malaria in pregnancy is a serious complication associated with parasitized erythrocyte (PE)
sequestration in the placenta. Recent work suggests that var genes could play an important …
sequestration in the placenta. Recent work suggests that var genes could play an important …
Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants
L Barfod, T Dobrilovic, P Magistrado… - The Journal of …, 2010 - journals.aai.org
Acquired protection from Plasmodium falciparum placental malaria, a major cause of
maternal, fetal, and infant morbidity, is mediated by IgG specific for the P. falciparum …
maternal, fetal, and infant morbidity, is mediated by IgG specific for the P. falciparum …
Dynamics of anti-VAR2CSA immunoglobulin G response in a cohort of senegalese pregnant women
NG Tuikue Ndam, A Salanti… - The Journal of …, 2006 - academic.oup.com
Background Pregnancy-associated malaria (PAM) is precipitated by the accumulation of
parasites in the placental intervillous spaces and causes maternal anemia and low birth …
parasites in the placental intervillous spaces and causes maternal anemia and low birth …
Positive Selection of Plasmodium falciparum Parasites With Multiple var2csa-Type PfEMP1 Genes During the Course of Infection in Pregnant Women
Placental malaria infections are caused by Plasmodium falciparum–infected red blood cells
sequestering in the placenta by binding to chondroitin sulfate A, mediated by VAR2CSA, a …
sequestering in the placenta by binding to chondroitin sulfate A, mediated by VAR2CSA, a …
A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?
JYA Doritchamou, JP Renn, L Hviid, PE Duffy - PLoS Pathogens, 2023 - journals.plos.org
VAR2CSA is the Plasmodium falciparum variant surface antigen that mediates binding of
infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous …
infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous …
Cross-Reactive Surface Epitopes on Chondroitin Sulfate A-Adherent Plasmodium falciparum-Infected Erythrocytes Are Associated with Transcription of var2csa
SR Elliott, MF Duffy, TJ Byrne, JG Beeson… - Infection and …, 2005 - Am Soc Microbiol
Malaria in pregnancy is associated with placental accumulation of Plasmodium falciparum-
infected erythrocytes (IE) that adhere to chondroitin sulfate A (CSA). Adhesion is mediated …
infected erythrocytes (IE) that adhere to chondroitin sulfate A (CSA). Adhesion is mediated …
Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies
Abstract Background Malaria caused by Plasmodium falciparum can result in several
different syndromes with severe clinical consequences for the about 200 million individuals …
different syndromes with severe clinical consequences for the about 200 million individuals …
High levels of antibodies to multiple domains and strains of VAR2CSA correlate with the absence of placental malaria in Cameroonian women living in an area of high …
YL Tutterrow, M Avril, K Singh, CA Long… - Infection and …, 2012 - Am Soc Microbiol
Placental malaria, caused by sequestration of Plasmodium falciparum-infected erythrocytes
in the placenta, is associated with increased risk of maternal morbidity and poor birth …
in the placenta, is associated with increased risk of maternal morbidity and poor birth …
Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites
P Fernandez, NK Viebig, S Dechavanne, C Lépolard… - Malaria Journal, 2008 - Springer
Background Pregnancy-associated malaria (PAM) is a serious consequence of Plasmodium
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …