Plasmodium falciparum and chondroitin-4-sulfate: the new key couple in sequestration

B Pouvelle, T Fusai, J Gysin - … Tropicale: Revue du Corps de Sante …, 1998 - europepmc.org
Some complications of Plasmodium falciparum infection such as cerebral malaria and
pregnancy-associated malaria may be partially due to cytoadherence of erythrocytes …

Sequestration of Plasmodium falciparum–infected erythrocytes to chondroitin sulfate A, a receptor for maternal malaria: monoclonal antibodies against the native …

JB Lekana Douki, B Traore, FTM Costa… - Blood, The Journal …, 2002 - ashpublications.org
Plasmodium falciparum parasites express variant adhesion molecules on the surface of
infected erythrocytes (IEs), which act as targets for natural protection. Recently it was shown …

High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

PA Magistrado, D Minja, J Doritchamou, NT Ndam… - Vaccine, 2011 - Elsevier
Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant
death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before …

Development of Antibodies against Chondroitin Sulfate A-Adherent Plasmodium falciparum in Pregnant Women

B Maubert, N Fievet, G Tami, M Cot… - Infection and …, 1999 - Am Soc Microbiol
In areas where Plasmodium falciparum is endemic, pregnant women are at increased risk
for malaria, and this risk is greatest during the first pregnancy. The placenta sequesters …

The influence of sub-unit composition and expression system on the functional antibody response in the development of a VAR2CSA based Plasmodium falciparum …

MA Nielsen, M Resende, WA de Jongh, SB Ditlev… - PLoS …, 2015 - journals.plos.org
The disease caused by Plasmodium falciparum (Pf) involves different clinical manifestations
that, cumulatively, kill hundreds of thousands every year. Placental malaria (PM) is one such …

Insight into Antigenic Diversity of VAR2CSA-DBL5ε Domain from Multiple Plasmodium falciparum Placental Isolates

S Gnidehou, L Jessen, S Gangnard, C Ermont… - PLoS …, 2010 - journals.plos.org
Background Protection against pregnancy associated malaria (PAM) is associated with high
levels of anti-VAR2CSA antibodies. This protection is obtained by the parity dependent …

Cytoadhesion of Plasmodium falciparum–infected erythrocytes to chondroitin-4-sulfate is cooperative and shear enhanced

H Rieger, HY Yoshikawa, K Quadt… - Blood, The Journal …, 2015 - ashpublications.org
Infections with the human malaria parasite Plasmodium falciparum during pregnancy can
lead to severe complications for both mother and child, resulting from the cytoadhesion of …

[HTML][HTML] Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies

P Khunrae, M Dahlbäck, MA Nielsen… - Journal of molecular …, 2010 - Elsevier
Plasmodium falciparum malaria remains one of the world's leading causes of human
suffering and poverty. Each year, the disease takes 1–3 million lives, mainly in sub-Saharan …

Towards the rational design of a candidate vaccine against pregnancy associated malaria: conserved sequences of the DBL6ε domain of VAR2CSA

C Badaut, G Bertin, T Rustico, N Fievet… - PLoS …, 2010 - journals.plos.org
Background Placental malaria is a disease linked to the sequestration of Plasmodium
falciparum infected red blood cells (IRBC) in the placenta, leading to reduced materno-fetal …

Role of Chondroitin‐4‐Sulfate in Pregnancy‐Associated Malaria

DC Gowda - Advances in Pharmacology, 2006 - Elsevier
Publisher Summary Many pathogenic microorganisms use glycosaminoglycans (GAGs) as
receptors for cell‐or tissue‐specific invasion, causing infection. In the case of pregnancy …