Improved Pregnancy Outcomes in Women Exposed to Malaria With High Antibody Levels Against Plasmodium falciparum

A Mayor, U Kumar, A Bardají, P Gupta… - The Journal of …, 2013 - academic.oup.com
Abstract Background. Antibodies against VAR2CSA, the Plasmodium falciparum variant
surface antigen that binds placental chondroitin sulfate A, have been suggested to mediate …

Multiplexing detection of IgG against Plasmodium falciparum pregnancy-specific antigens

AM Fonseca, L Quinto, A Jimenez, R Gonzalez… - PLoS …, 2017 - journals.plos.org
Background Pregnant women exposed to Plasmodium falciparum generate antibodies
against VAR2CSA, the parasite protein that mediates adhesion of infected erythrocytes to …

Parity and Placental Infection Affect Antibody Responses against Plasmodium falciparum during Pregnancy

A Mayor, E Rovira-Vallbona, S Machevo… - Infection and …, 2011 - Am Soc Microbiol
Women are at higher risk of Plasmodium falciparum infection when pregnant. The
decreasing risk of malaria with subsequent pregnancies is attributed to parity-dependent …

Differential Recognition of P. falciparum VAR2CSA Domains by Naturally Acquired Antibodies in Pregnant Women from a Malaria Endemic …

KJM Brolin, KEM Persson, M Wahlgren, SJ Rogerson… - PLoS …, 2010 - journals.plos.org
Background Plasmodium falciparum infected red blood cells (iRBC) express variant surface
antigens (VSA) of which VAR2CSA is involved in placental sequestration and causes …

Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria

M Fried, M Avril, R Chaturvedi, P Fernandez… - Infection and …, 2013 - Am Soc Microbiol
Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes that adhere to
the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women …

Rapid Acquisition of Isolate-Specific Antibodies to Chondroitin Sulfate A-Adherent Plasmodium falciparum Isolates in Ghanaian Primigravidae

SE Cox, T Staalsoe, P Arthur, JN Bulmer… - Infection and …, 2005 - Am Soc Microbiol
Recent evidence suggests that pregnancy-associated malaria (PAM), associated with
maternal anemia and low birth weight, results from preferential sequestration of parasitized …

Identification of a 67‐amino‐acid region of the Plasmodium falciparum variant surface antigen that binds chondroitin sulphate A and elicits antibodies reactive with …

B Gamain, JD Smith, M Avril, DI Baruch… - Molecular …, 2004 - Wiley Online Library
The complications of malaria in pregnancy are caused by the massive sequestration of
parasitized erythrocytes (PE) in the placenta. Placental isolates of Plasmodium falciparum …

Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: impact on vaccine design for placental malaria

B Bordbar, NT Ndam, E Renard… - Infection, Genetics and …, 2014 - Elsevier
In placental malaria (PM), sequestration of infected erythrocytes in the placenta is mediated
by an interaction between VAR2CSA, a Plasmodium falciparum protein expressed on …

Dynamics in the Cytoadherence Phenotypes of Plasmodium falciparum Infected Erythrocytes Isolated during Pregnancy

J Doritchamou, S Sossou-Tchatcha, G Cottrell… - PLoS …, 2014 - journals.plos.org
Pregnant women become susceptible to malaria infection despite their acquired immunity to
this disease from childhood. The placental sequestration of Plasmodium falciparum infected …

Can any lessons be learned from the ambiguous glycan binding of PfEMP1 domains?

M Dahlbäck, MA Nielsen, A Salanti - Trends in parasitology, 2010 - cell.com
Pregnancy-associated malaria (PAM) is caused by Plasmodium falciparum-infected
erythrocytes (IEs) accumulating in the placenta and has dire consequences for both mother …