Reports an error in" Dopamine D2 receptors in addiction-like reward dysfunction and
compulsive eating in obese rats" by Paul M. Johnson and Paul J. Kenny (Nature …

We found that development of obesity was coupled with the emergence of a progressively
worsening brain reward deficit. Similar changes in reward homeostasis induced by cocaine …

We found that development of obesity was coupled with emergence of a progressively
worsening deficit in neural reward responses. Similar changes in reward homeostasis …

In 2010, Johnson and Kenny provided conclusive evidence that extended access to a
Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors …

Background The dopamine D 2 receptor (D 2 R) has received much attention in obesity
studies. Data indicate that D 2 R is reduced in obesity and that the TaqA1 D 2 R variant may …

Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic
dopaminergic pathway. Changes in DA signaling in mesolimbic neurotransmission are …

The role of the dopamine D2 receptor (D2R) in regulating appetitive behavior continues to
be controversial. Earlier literature suggests that reduced D2R signaling diminishes …

The obesity epidemic is believed to be driven by a food environment that promotes
consumption of inexpensive, convenient, high-calorie, palatable foods. Individual …

A decrease in D2-like receptor (D2R) binding in the striatum has been reported in obese
individuals and drug addicts. Although natural and drug rewards share neural substrates, it …

The nucleus accumbens (NAcc) mediates feeding reward; its activity reflects tastants'
hedonic value. NAcc dopamine guides immediate responses to reward, however, its …