Obesity is typically associated with abnormal eating behaviors. Brain imaging studies in
humans implicate the involvement of dopamine (DA)-modulated circuits in pathologic eating …

Dieting as a strategy to reduce body weight often fails as it causes food cravings leading to
bingeing and weight regain. Evidence from several lines of research suggests the presence …

Dopaminergic signaling in the striatum, particularly at dopamine 2 receptors (D2R), has
been a topic of active investigation in obesity research in the past decades. However, it still …

Highlights•Obesity and addiction result in diminished D2 receptor availability in striatum.•D2
receptors control compulsive eating.•DREADDs and optogenetics have revealed a key role …

Dopamine (DA) signaling has been implicated in the control of energy balance and
ingestive behavior. In the present study, we sought to characterize body weight, body fat and …

The dopamine D3 receptor is thought to be a potential target for treating compulsive
disorders such as drug addiction and obesity. Here, we used functional Magnetic …

Background Obesity has reached global epidemic proportions and is associated with
serious medical comorbidities and economic consequences. In this preclinical study, we …

The present study examined brain dopamine D2 and D4 receptor and tyrosine hydroxylase
(TH) mRNA expression in chronic high-fat diet-induced obese (cDIO) and obese-resistant …

Chronic overeating of obesogenic diets can lead to obesity, reduced dopamine signaling,
and increased consumption of added sugars to compensate for blunted reward. However …

Dopamine signaling has been implicated in the control of food intake and body weight. In
particular, dopamine is important in the control of meal size and number and is thought to …