Data suggest that low levels of dopamine D2 receptors and attenuated responsivity of
dopamine-target regions to food intake is associated with increased eating and elevated …

Objective: A rat model of diet-induced obesity (DIO) was used to determine dopamine
transporter (DAT) function, impulsivity and motivation as neurobehavioral outcomes and …

Compulsive eating behavior is hypothesized to be driven in part by reward deficits likely due
to neuroadaptations to the mesolimbic dopamine (DA) system. Therefore, the aim of this …

Highlights•Chronic high-fat feeding modulates dopamine tone and function.•The impact of
high-fat diet on dopamine-related endpoints is inconsistent.•Classification of results …

Stimulation or blockade of various dopamine receptor subtypes is associated with reduced
feeding. For example, D2 receptor agonists suppress feeding in food‐deprived and free …

As revealed by previous microdialysis studies, basal and food intake-accompanied
dopamine release significantly differs in the hypothalamus of obese vs. lean Zucker rats. In …

Obesity is a major public health problem. The increasing number of obese individuals in the
US adds urgency to the efforts to understand the mechanisms underlying pathological …

Hedonic overconsumption contributing to obesity involves altered activation within the
mesolimbic dopamine system. Dysregulation of dopamine signaling in the nucleus …

How can drug addiction help us understand obesity? | Nature Neuroscience Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Altered mesolimbic dopamine signaling has been widely implicated in addictive behavior.
For the most part, this work has focused on dopamine within the striatum, but there is …