Dopamine (DA) is considered crucial for the rewarding effects of drugs of abuse, but its role
in addiction is much less clear. This review focuses on studies that used PET to characterize …

A decrease in dopamine D2 receptor (D2R) binding in the striatum is one of the most
common findings in disorders that involve a dysregulation of motivation, including obesity …

Obese humans and animals exhibit reduced functioning of the dopamine (DA) system in the
nucleus accumbens (NAc). The question addressed here is whether this change in NAc DA …

Dysregulation of the dopamine system is linked to various aberrant behaviors, including
addiction, compulsive exercise, and hyperphagia leading to obesity. The goal of the present …

The association between dietary obesity and mesolimbic systems that regulate hedonic
aspects of feeding is currently unresolved. In the present study, we examined differences in …

Rationale Bulimia nervosa (BN) is highly comorbid with substance abuse and shares
common phenotypic and genetic predispositions with drug addiction. Although treatments …

A decrease in D2 dopamine receptor subtype (D2R) binding in the striatum has been
reported in obese individuals and drug addicts. We examined D2R density in the striatum of …

The drive for food is one of the most powerful of human and animal behaviors. Dopamine, a
neurotransmitter involved with motivation and reward, its believed to regulate food intake in …

Behaviours such as eating, copulating, defending oneself or taking addictive drugs begin
with a motivation to initiate the behaviour. Both this motivational drive and the behaviours …

Rationale Adolescents are often described as “lacking brakes” resulting in an increase in
several behaviors associated with risk for addiction. Prefrontal cortex dopamine and cortico …