Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and it is
characterised by progressive deterioration in cognitive and memory abilities, which can …

The innate immune system and inflammatory response in the brain have critical impacts on
the pathogenesis of many neurodegenerative diseases including Alzheimer's disease (AD) …

In an ageing society, neurodegenerative diseases have attracted attention because of their
high incidence worldwide. Despite extensive research, there is a lack of conclusive insights …

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common
neurodegenerative diseases. Many studies have demonstrated that the release of NLRP3 …

Background Neuroinflammation has an essential impact on the pathogenesis and
progression of Alzheimer's disease (AD). Mostly mediated by microglia and astrocytes …

Highlights•Host-derived molecules (eg β-amyloid, tau) trigger NLRP3 inflammasome
signaling.•TNF, ATP, serum amyloid A and the microbiome regulate NLRP3 inflammasome …

Innate immunity and inflammatory response plays an important role in the pathogenesis of
Alzheimer's disease (AD). As the major resident immune cells in the brain, microglial cells …

Aging-related, nonresolving inflammation in both the central nervous system (CNS) and
periphery predisposes individuals to the development of neurodegenerative disorders …

Alzheimer's disease (AD) is the most common cause of dementia in the general population
and, to date, constitutes a major therapeutic challenge. In the pathogenesis of AD …

The nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor
protein 3 (NLRP3) is an important pattern recognition receptor in human innate immunity …